Does removing more normal liver tissue raise the risk of liver failure after liver resection?

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Investigators performed a large retrospective review of over a thousand consecutive patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma who underwent selective hepatectomy at multiple Chinese centers. They calculated resected normal liver parenchymal volume (RNLV) from imaging and operative data and recorded post-hepatectomy liver failure (PHLF) according to 50-50 and ISGLS criteria. The team planned to build a predictive model combining RNLV with clinical variables and compare its performance to future liver remnant (FLR) metrics, with special attention to patients with large or multiple tumors. The goal was to see whether RNLV can be an informative variable for preoperative risk stratification and surgical safety planning.

Why it matters

Who can join: the full rules

Inclusion criteria:

* selective hepatectomies;
* histologically confirmed as HCC and ICC
* complete and accessible data

Exclusion criteria:

* any history of Associated Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS)
* any history of portal vein embolism (PVE)
* any history of tumor rupture
* emergency surgery
* pathologically diagnosed with neither HCC nor ICC
* concomitant resection of gastrointestinal organs, spleenectomy or other organs

Where it's running

• Mengchao Hepatobiliary Hospital of Fujian Medical University
  Fujian, Shanghai Municipality, China Recruiting
• The Third Affiliated Hospital of Naval Medical University
  Shanhai, Shanghai Municipality, China Recruiting
• Cancer Hospital Chinese Academy of Medical Sciences, Shenzhen, Mengchao Hepatobiliary Hospital of Fujian Medical University
  Shenzhencun, Shanghai Municipality, China Recruiting

Study contacts

• Study coordinator: Yuan-yuan Wang
• Email: wangyuanyuan702@foxmail.com
• Phone: +8615800332525

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.