Investigating how energy production in mitochondria affects liver health
Official title: The role of mitochondrial ATP production in liver failure
Funded at Ut Southwestern Medical Center · NIH-11023057 · Data updated 2026-11-12
This study is looking at how problems with energy production in liver cells might affect conditions like nonalcoholic fatty liver disease and liver failure, using a special mouse model to help find new ways to treat these liver issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $40,049 |
| NIH project number | 5F30DK137407-02 |
| Project ID | NIH-11023057 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from liver diseases, particularly those with nonalcoholic fatty liver disease or liver failure.
✕Less likely to help
Patients with liver conditions unrelated to mitochondrial dysfunction may not benefit from this research.
What this research studies
This research focuses on understanding the role of mitochondrial energy production in liver diseases such as nonalcoholic fatty liver disease and liver failure. Using a newly developed mouse model, the study will explore the physiological effects of disrupted mitochondrial function in the liver. Researchers will employ advanced techniques like mass spectrometry, nuclear magnetic resonance, and specialized assays to analyze how changes in mitochondrial ATP production impact liver health. The findings could provide insights into potential therapeutic targets for liver-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for liver diseases by targeting mitochondrial dysfunction.
How similar studies have gone: Previous research has shown that targeting mitochondrial dysfunction can lead to significant improvements in related health conditions, suggesting a promising avenue for this investigation.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Menezes, Cameron Joseph — Ut Southwestern Medical Center
- Study coordinator: Menezes, Cameron Joseph
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.