Evaluating citrate anticoagulation in kidney treatment for liver failure patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study examines the efficacy and safety of citrate anticoagulation during continuous renal replacement therapy (CRRT) in critically ill patients suffering from liver failure and acute kidney injury (AKI). It aims to determine how the underlying cause of liver failure affects the incidence of citrate-related complications and to compare outcomes such as renal recovery and patient survival. The study will analyze data retrospectively to assess the impact of citrate anticoagulation on filter lifespan and overall patient outcomes in this vulnerable population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Critically ill patients diagnosed with AKI requiring CRRT. Caution Protocol V1.0 24-07-2024
* Documented liver failure or significant liver dysfunction (e.g., elevated liver enzymes, bilirubin levels, or clinical diagnosis of liver failure) and clincal diagnosis of shock (NE of 0.25 μg/kg/min and or association of second vasopressor).
* Age ≥ 18 years.

Exclusion Criteria:

* NA

Where it's running

• Antwerp University Hospital
  Edegem, Antwerp, Belgium Recruiting

Study contacts

• Principal investigator: Rita Jacobs, Dr. — Antwerp Univesity Hospital
• Study coordinator: Rita Jacobs, Dr.
• Email: rita.jacobs2@uza.be
• Phone: +32 3 821 36 35

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.