Understanding how CD8 T cells and liver macrophages interact to cause pediatric acute liver failure
Official title: Elucidating Effector CD8 T-Cell – Kupffer Cell InterferonGamma Interaction in Pediatric Activated T-cell Acute Liver Failure
Funded at Children's Hosp of Philadelphia · NIH-11415760 · Data updated 2026-11-12
A mentoring-based research effort aims to understand how immune cells in the liver contribute to severe liver failure in children.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 15, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $159,408 |
| NIH project number | 5K08DK141964-02 |
| Project ID | NIH-11415760 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children aged 0-11 years with or at risk for pediatric activated T-cell acute liver failure may be eligible for related studies or future trials.
✕Less likely to help
Children without PALF or unrelated liver conditions may not directly benefit from this specific research.
What this research studies
This grant supports a clinician-scientist as they become an independent investigator in liver immunology. The project focuses on how effector CD8 T cells and Kupffer cells communicate through interferon-gamma to drive pediatric acute liver failure. The work will combine patient-relevant blood and liver tissue insights with translational studies, mentored by an experienced investigator. Over five years, the researcher will develop skills and generate data to guide future therapies for PALF. This is a physician-scientist training grant that advances clinical and laboratory investigation in a pediatric liver disease context.
Why it matters
Potential benefit: If successful, the research could illuminate targets to prevent or treat pediatric acute liver failure.
How similar studies have gone: Previous work in liver immunology supports the importance of CD8 T cells and Kupffer cells in inflammatory liver disease, with promising translational potential.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Diamond, Tamir — Children's Hosp of Philadelphia
- Study coordinator: Diamond, Tamir
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.