Platelet-Rich Plasma from Two Different Systems in Knee Osteoarthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This phase 4 interventional study evaluates differences in the quality of platelet-rich plasma produced by two commercial systems in adults with knee osteoarthritis. Participants will receive PRP prepared with either the APEX Biologix XCELL PRP System or the Emcyte PurePRP system, and outcomes on knee symptoms will be tracked after injection. The study also examines whether the two preparation methods yield PRP with different platelet counts or functional properties. Eligibility includes adults with KL grade 1–3 OA, persistent knee symptoms, and ability to participate in physical therapy. Exclusion criteria cover recent injections, prior knee surgeries, bleeding disorders, immunocompromise, active cancer, and other knee-affecting conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Kellgren-Lawrence (KL) Grade 1-3 knee osteoarthritis
* Symptoms of knee osteoarthritis for at least 3 months before presentation in one knee
* Will be able to attend and perform physical therapy

Exclusion Criteria:

* Received injection therapy for knee osteoarthritis in the past 6 months
* Have severe arthritis diagnosed in ≥1 major joint by radiology criteria
* History of septic arthritis
* Underwent knee surgery for osteoarthritis or osteochondral defects within 1 year before randomization (e.g., autograft or allograft surgery)
* Have had high tibial osteotomy, partial knee replacement, patellar resurfacing, total knee replacement, or have existing surgical hardware in the knee
* Received a platelet-rich plasma injection elsewhere in the body within the past 3 months
* Have a platelet disorder or bleeding disorder
* Have a rheumatologic disease, autoimmune disorder, immunocompromised status, or active history of cancer
* Are taking chemotherapy, require regular prednisone, or require regular anti-inflammatory use
* Are pregnant, breastfeeding, or unwilling to practice birth control during the study
* If both knees have osteoarthritis and the other knee has KL score equal to or greater than 2.
* Have uncontrolled illness, physical disability, or other contraindication to aerobic exercise training

Where it's running

• University of California San Francisco
  San Francisco, California, United States Recruiting

Study contacts

• Principal investigator: Anthony Luke, MD — University of California, San Francisco
• Study coordinator: Joel Kopcow
• Email: joel.kopcow@ucsf.edu
• Phone: 970-590-0314

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.