Frozen versus fresh platelet-rich plasma injections for knee osteoarthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants with radiographically confirmed knee osteoarthritis and symptomatic pain will receive intra-articular injections of platelet-rich plasma prepared either from frozen-stored samples or applied at the time of collection. The two injection approaches will be compared for safety and clinical outcomes such as pain and function over a defined follow-up period. Key eligibility includes age 40–85, BMI 20–35, Ahlbäck radiological grades 1–3, and KOOS pain ≤75. Patients with recent intra-articular corticosteroid/PRP injections, systemic autoimmune disease, significant deformity, or hematologic disorders are excluded.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients of both sexes.
* Aged between 40 and 85 years old.
* Diagnosed with osteoarthritis through clinical radiological examination.
* Joint pain equal to or less than 75 points on the KOOS (pain).
* Radiological severity grades 1, 2, and 3 according to the Ahlbäck scale.
* Indication for intra-articular PRP infiltration.
* Body Mass Index values between 20 and 35.
* Negative serological tests for syphilis, HIV, HBV, and HCV.
* Possibility of observation during the follow-up period.
* Signature of informed consent.

Exclusion Criteria:

* Body mass index \>35
* Diagnosed polyarticular disease.
* Previous arthroscopy in the last year.
* Severe mechanical deformity.
* Intra-articular hyaluronic acid injection in the last 12 months.
* Intra-articular corticosteroid or PRP injection in the last 6 months.
* Systemic autoimmune rheumatic disease (connective tissue diseases and systemic necrotizing vasculitis).
* Anemia or other hematological disorders.
* Positive serological tests for SYPHILIS, HIV, HBV, and HCV.
* Undergoing immunosuppressive treatments.
* Poorly controlled diabetes mellitus.
* Patients allergic to paracetamol.
* Pregnancy or breastfeeding.

Where it's running

• Arthroscopic Surgery Unit, MiKS Hosptial
  Vitoria-Gasteiz, Araba/Álava, Spain Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.