Clinical trial Recruiting at 1 site Interventional Ages 40 to 65

Aquatic exercise for knee osteoarthritis and central sensitization

Official title: The Effect of Aquatic Exercise on Central Sensitization and Functional Parameters in Patients With Knee Osteoarthritis: a Randomized Controlled Trial

Run by Kirsehir Ahi Evran Universitesi · NCT07883824 · Data updated 2026-11-12

A water-based exercise program is being tested to see if it helps people aged 40–65 with knee osteoarthritis who also have central sensitization.

Quick facts

Study typeInterventional
Ages40 Years to 65 Years
SexAll
Enrollment60 (estimated)
SponsorKirsehir Ahi Evran Universitesi
Academic / other
Locations1 site (Kırşehir, Merkez)
StatusRecruiting
StartedJune 1, 2026
Main results expectedDecember 1, 2026
Study endsFebruary 1, 2027
Registry record updatedNovember 4, 2026
Trial IDNCT07883824 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 40–65 with knee osteoarthritis and central sensitization who do not have cognitive impairments or recent knee surgery.

Probably not a fit

Participants with cognitive impairment, recent knee surgery, fracture, malignancy, infection, or pregnancy may not benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study uses standard physical therapy and hydrotherapy to explore whether aquatic exercise can reduce central sensitization and improve functional outcomes in adults with knee osteoarthritis. It will assess changes in pain processing, balance, and quality of life. The trial is conducted at Kirsehir Ahi Evran University in Turkey and involves volunteers meeting specific eligibility criteria. Results could help clarify if water-based exercise benefits this patient group beyond traditional therapy.

Why it matters

Potential benefit: If successful, participants may experience reduced pain sensitivity and better knee function through aquatic exercise.

How similar studies have gone: Previous research in related areas suggests aquatic therapy can help knee OA and pain, but specific effects on central sensitization are less established.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Adults aged 40-65
2. Individuals diagnosed with knee osteoarthritis
3. Individuals with no cognitive impairments
4. Volunteers for the study

Exclusion Criteria:

1. Individuals who have undergone knee surgery
2. Individuals presenting with signs such as fracture, malignancy, or infection
3. Pregnancy
4. Individuals with cognitive impairments who are unable to express themselves.

Where it's running

  • Kirsehir Ahi Evran University, Kırşehir, Merkez 40100
    Kırşehir, Merkez, Turkey (Türkiye)
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.