Condition

Inflammatory Disease clinical trials and research

• 12Clinical trials
• 26NIH research projects
• 5Countries

Newest Inflammatory Disease clinical trials

All recruiting trials (12)

• Multimodal Eye Data Bank to Explore Inflammation-Related Eye Diseases

  This observational effort collects rich eye-imaging data from people with inflammatory and retinal conditions to see how the front and back of the eye relate and to build a standardized database that could support future AI tools.

  Recruiting Capital Medical University · Beijing · NCT07628946

• Clinical features, treatments, and outcomes in inflammation-associated non-rapidly-progressive coronary artery disease

  This study will see how current treatments, inflammation markers, and patient characteristics relate to outcomes in people with inflammation-associated non-rapidly-progressive coronary artery disease (INR-CAD).

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT06845410

• 68Ga-FAPI46 PET/CT for chronic inflammatory and fibrotic diseases

  We will try a new PET/CT scan using 68Ga-FAPI46 to see if it helps detect and monitor chronic inflammatory and fibrotic conditions in adults.

  Recruiting University Hospital, Brest · Brest · NCT06275477

• Treatment with Subcutaneous Infliximab for Crohn's Disease

  This study is testing if a new way of giving infliximab can help people with moderate to severe Crohn's disease feel better without needing steroids.

  Recruiting Phase 3 Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam, North Holland · NCT06059989

• Investigating characteristics of a special type of coronary artery disease

  This study is trying to understand the unique features of a fast-progressing type of coronary artery disease by comparing patients with this condition to those with a more common form of the disease.

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT06007248

• Evaluating comprehensive treatment for rapidly-progressive coronary artery disease

  This study is testing a new treatment plan for people with rapidly-progressive coronary artery disease that includes medication and procedures to see if it helps them feel better and manage their condition.

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT05860400

• Using advanced MRI to understand how Filgotinib relieves pain in rheumatoid arthritis

  This study is testing how Filgotinib helps relieve pain in people with rheumatoid arthritis by looking at brain activity and inflammation.

  Recruiting NHS Greater Glasgow and Clyde · Glasgow · NCT05697159

• Identifying genes in systemic autoinflammatory diseases

  This study is trying to find new genes linked to rare autoinflammatory diseases to help doctors diagnose and treat patients better.

  Recruiting Institut National de la Santé Et de la Recherche Médicale, France · Paris · NCT05364294

• Evaluating how high doses of prednisolone affect patients with inflammatory conditions

  This study is trying to see how different doses of prednisolone affect patients with inflammatory conditions by looking at their blood levels and how their bodies process the medication.

  Recruiting Imperial College London · London · NCT05012033

• Investigating genetic variants affecting inflammation regulation

  This study is trying to see if certain genetic changes in South Asian people affect how their bodies handle inflammation and could lead to chronic inflammatory diseases.

  Recruiting Queen Mary University of London · London · NCT04698291

• Studying how genetic testing can improve medication use in patients

  This study is trying to see if using genetic testing can help doctors choose the right medications for patients with heart diseases, inflammatory bowel diseases, and autoimmune diseases to improve their treatment outcomes.

  Recruiting University of Chicago · Chicago, Illinois · NCT01280825

• Characterizing patients with rare cardiovascular diseases

  This study is trying to learn more about rare heart diseases by testing people who have these conditions, their family members, and healthy volunteers to see how these diseases develop and what causes them.

  Recruiting at 2 sites National Institutes of Health Clinical Center (CC) · Washington D.C., District of Columbia and 2 other locations · NCT01143454

NIH-funded research (26)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Glutathionylated products from lipid oxidation in eye disease

  This project studies how lipid-oxidation products in the eye might drive age-related macular degeneration and related conditions, by looking at molecules that behave like inflammatory signals.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11398241

• Inflammation risks in clonal hematopoiesis and cancer

  This grant studies how clonal hematopoiesis may drive inflammatory diseases and helps predict who is at risk so doctors can prevent complications in people with blood cancers.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11394516

• IgE responses to alpha-gal and how they relate to allergic disease

  This project studies why some people develop allergic reactions to mammal products due to alpha-gal and what this means for diagnosing and managing the condition.

  NIH research University of Virginia · Charlottesville, United States · NIH-11385950

• Alpha‑gal allergy: delayed reactions to red meat and mammal‑derived products

  Researchers are looking at why some adults get delayed allergic reactions hours after eating mammal products (alpha‑gal) and how to better diagnose and manage them.

  NIH research University of Virginia · Charlottesville, United States · NIH-11370743

• A signaling switch that keeps inflammation in check in lupus-like disease

  Researchers study how a signaling module in immune cells controls inflammation linked to lupus by examining proteins that turn inflammation on and off.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11361703

• Gut bacteria and steroid hormones in inflammatory bowel disease

  A study in people and mice looks at how gut bacteria may change steroids that reduce inflammation in inflammatory bowel disease.

  NIH research University of Chicago · Chicago, United States · NIH-11356380

• Exploring Molecules Linked to Eye Inflammation and Retinal Damage

  This project aims to understand how certain molecules, called pseudo leukotrienes, contribute to eye conditions like age-related macular degeneration by studying them in the retina.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11321907

• Copper uptake transporter as a sensor in blood vessel inflammation

  A scientist-led study will explore how a copper transporter in blood vessel cells acts as a sensor that may drive inflammation and a new cell-death pathway linked to atherosclerosis.

  NIH research Augusta University · Augusta, United States · NIH-11309673

• Targeting CD4 T cell metabolism to reduce inflammation in autoimmune disease

  Researchers are trying to block a metabolism enzyme in certain CD4 immune cells to calm harmful inflammation in conditions like inflammatory bowel disease.

  NIH research University of Chicago · Chicago, United States · NIH-11262862

• Making standardized live bacterial medicines for C. difficile and gut inflammation

  Developing reliable ways to produce live bacterial medicines that can replace donor stool for people with recurrent C. difficile and other gut inflammation.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11261767

• Stopping harmful inflammation from bacterial infections by targeting RIPK2

  Researchers are developing drugs that block a protein called RIPK2 to reduce damaging inflammation in people with certain bacterial infections or inflammatory conditions.

  NIH research National Jewish Health · Denver, United States · NIH-11261104

• How glutathione-linked breakdown of retinal fats may drive inflammation in age-related macular degeneration

  This project is seeing if glutathione-linked breakdown products of retinal fats trigger inflammation that contributes to age-related macular degeneration (AMD).

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11166490

• Role of brain-resident and incoming immune cells in inflammatory brain damage

  The team uses targeted drug-delivery tools to find out whether brain‑resident microglia or incoming blood immune cells drive brain damage in people after injury, infection, or autoimmune disease.

  NIH research University of Oklahoma · Norman, United States · NIH-11144336

• Understanding Cell Signals in Inflammatory Diseases like Lupus

  This project explores how specific cell signals contribute to inflammatory conditions such as lupus, aiming to discover new ways to help patients.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11117052

• Allergic reactions to alpha-gal in mammal-derived foods and medicines

  This work looks at why some adults get delayed allergic reactions to red meat and certain medicines after tick exposure and how to better detect and manage those reactions.

  NIH research University of Virginia · Charlottesville, United States · NIH-11097384

• Investigating how copper transport affects inflammation in blood vessels

  This study is looking at how a special copper transporter in blood vessel cells reacts to changes in blood flow and how it might play a role in inflammation and cell damage related to atherosclerosis, which can lead to heart disease.

  NIH research Augusta University · Augusta, United States · NIH-11061860

• Understanding how immune cells respond to bacterial infections

  This study is looking at how a protein in your immune cells helps them fight off bacterial infections, and it's for anyone interested in finding new ways to manage conditions caused by too much inflammation, like allergies or autoimmune diseases.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11042711

• Creating defined live microbial treatments for infections and inflammation

  This study is testing a new treatment made from specially grown bacteria to help people with recurring Clostridioides difficile infections, aiming to see if it's more effective and safer than traditional stool transplants.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11024873

• Understanding how clonal hematopoiesis affects inflammatory diseases

  This study is looking at how a condition called clonal hematopoiesis, where certain blood cells grow due to mutations, might be connected to inflammatory diseases like arthritis, and it aims to help predict who might be at risk for these issues and how different treatments can affect symptoms.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-10982741

• Predicting disability worsening and inflammation in multiple sclerosis using advanced algorithms

  This study is looking at how to better predict changes in disability and inflammation for people with multiple sclerosis, using data from medical records to help create personalized treatment plans that could improve their care.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10932157

• Investigating the role of specific lipid oxidation products in eye diseases.

  This study is looking at how certain substances that come from fat breakdown might harm the retina in people with age-related macular degeneration (AMD), and it aims to find new ways to help treat this condition.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-10899606

• Investigating how immune cells contribute to brain damage in inflammatory diseases

  This study is looking at how certain immune cells can cause brain damage after injuries or autoimmune diseases, and it's for anyone interested in finding better treatments for brain injuries by using new ways to target these immune cells.

  NIH research University of Oklahoma · Norman, United States · NIH-10894057

• How inflammation affects bone healing and regeneration

  This study looks at how inflammation affects the healing of broken bones, especially for people with inflammatory diseases, and aims to find ways to help improve recovery by understanding the role of certain proteins and genes in bone repair.

  NIH research Washington University · Saint Louis, United States · NIH-10889023

• Investigating how certain proteins control inflammation linked to immune diseases.

  This study is looking at how certain proteins help control inflammation in the immune system, especially when it goes a bit haywire, which can lead to conditions like lupus, and it's aimed at finding new ways to treat these kinds of inflammatory diseases.

  NIH research University of Utah · Salt Lake City, United States · NIH-10868531

• Investigating the causes of Pelvic Inflammatory Disease in women

  This study is looking at what causes Pelvic Inflammatory Disease (PID) in young women by tracking a group of 1,199 women who are at higher risk for infections, to help find better ways to diagnose and treat this condition.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10668432

• Inflammation's role in a heart disease that can cause sudden death.

  This study is looking at how inflammation affects arrhythmogenic cardiomyopathy, a heart condition that can be especially risky for young athletes, and it aims to find out if exercise makes it worse and whether anti-inflammatory treatments can help keep hearts safer.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-10629180

Related topics

Quick answers

How many Inflammatory Disease clinical trials are recruiting right now?

12, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in China (4 trials), United Kingdom (3 trials), United States (2 trials), France (2 trials), Netherlands (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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