Investigating how certain proteins control inflammation linked to immune diseases.
Official title: A phospho-tyrosine-based signaling module controlling TLR-mediated inflammatory disease.
Funded at University of Utah · NIH-10868531 · Data updated 2026-11-12
This study is looking at how certain proteins help control inflammation in the immune system, especially when it goes a bit haywire, which can lead to conditions like lupus, and it's aimed at finding new ways to treat these kinds of inflammatory diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | July 7, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $734,968 |
| NIH project number | 5R01AI170942-03 |
| Project ID | NIH-10868531 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with systemic lupus erythematosus or other related inflammatory conditions.
✕Less likely to help
Patients with non-inflammatory conditions or those not affected by immune system disorders may not benefit from this research.
What this research studies
This research focuses on understanding the role of specific proteins in the immune response, particularly how they regulate inflammation caused by Toll-like receptors (TLRs). By studying mouse models and genetic interactions, the researchers aim to uncover the mechanisms that lead to inappropriate TLR activity, which can result in diseases like systemic lupus erythematosus (SLE). The approach involves examining protein interactions and phosphorylation events that influence immune responses, with the goal of identifying potential therapeutic targets for managing inflammatory diseases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from inflammatory diseases like lupus.
How similar studies have gone: Previous research has shown promising results in understanding TLR pathways and their role in inflammation, indicating that this approach has potential for success.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Haecker, Hans — University of Utah
- Study coordinator: Haecker, Hans
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.