Glutathionylated products from lipid oxidation in eye disease
Official title: Glutathionylated Products of Radical-Induced Lipid Oxidation in Inflammatory Disease
Funded at Case Western Reserve University · NIH-11398241 · Data updated 2026-11-12
This project studies how lipid-oxidation products in the eye might drive age-related macular degeneration and related conditions, by looking at molecules that behave like inflammatory signals.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $393,775 |
| NIH project number | 5R01EY034075-04 |
| Project ID | NIH-11398241 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals with retinal disease related to oxidative stress and AMD; future translational steps could involve patients with early AMD.
✕Less likely to help
People without retinal disease or those not exposed to oxidative stress likely would not benefit.
What this research studies
Researchers will explore how unusual lipid-derived molecules formed after oxidative stress affect retinal cells, using a rat model of light-induced retinal damage. They will identify the structures and activities of these glutathione-derived products and test whether they mimic leukotriene signals in the retina. The work aims to connect these molecules to changes in retinal cells and eye health, which could explain why current AMD treatments often have limited success. By understanding these pathways, the study hopes to reveal new targets for therapies and more accurate disease markers.
Why it matters
Potential benefit: If successful, this work could lead to new biomarkers and therapeutic targets for AMD and related retinal diseases.
How similar studies have gone: Preliminary findings show these glutathione-derived molecules exist in human retina and have leukotriene-like activities, supporting further study.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Salomon, Robert Gerd — Case Western Reserve University
- Study coordinator: Salomon, Robert Gerd
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.