Investigating the role of specific lipid oxidation products in eye diseases.
Official title: Glutathionylated Products of Radical-Induced Lipid Oxidation in Inflammatory Disease
Funded at Case Western Reserve University · NIH-10899606 · Data updated 2026-11-12
This study is looking at how certain substances that come from fat breakdown might harm the retina in people with age-related macular degeneration (AMD), and it aims to find new ways to help treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $394,272 |
| NIH project number | 5R01EY034075-02 |
| Project ID | NIH-10899606 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for or diagnosed with age-related macular degeneration.
✕Less likely to help
Patients with retinal diseases unrelated to oxidative stress or lipid metabolism may not benefit from this research.
What this research studies
This research focuses on understanding how certain products generated from lipid oxidation affect the retina, particularly in conditions like age-related macular degeneration (AMD). The team will explore the biological activities of these products, known as pseudo leukotrienes, which may mimic natural signaling molecules and contribute to retinal damage. By using a rat model of retinal degeneration, the researchers aim to uncover the mechanisms by which these lipid oxidation products influence cellular responses and potentially lead to new therapeutic strategies. This work is crucial for developing better disease markers and treatments for AMD.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic markers and more effective treatments for age-related macular degeneration.
How similar studies have gone: Previous research has shown promise in understanding lipid oxidation products in other contexts, but this specific approach to AMD is relatively novel.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Salomon, Robert Gerd — Case Western Reserve University
- Study coordinator: Salomon, Robert Gerd
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Glutathionylated products from lipid oxidation in eye disease
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.