Inflammation's role in a heart disease that can cause sudden death.
Official title: Arrhythmogenic Cardiomyopathy is an Inflammatory Disease
Funded at Beth Israel Deaconess Medical Center · NIH-10629180 · Data updated 2026-11-12
This study is looking at how inflammation affects arrhythmogenic cardiomyopathy, a heart condition that can be especially risky for young athletes, and it aims to find out if exercise makes it worse and whether anti-inflammatory treatments can help keep hearts safer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 1, 2020 |
| Project end | March 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $560,935 |
| NIH project number | 5R01HL148348-04 |
| Project ID | NIH-10629180 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with arrhythmogenic cardiomyopathy, especially those who are young and physically active.
✕Less likely to help
Patients with arrhythmogenic cardiomyopathy who are not physically active or do not have significant inflammatory responses may not benefit from this research.
What this research studies
This research investigates how inflammation contributes to arrhythmogenic cardiomyopathy (ACM), a serious heart condition that can lead to sudden death, particularly in young athletes. The study aims to understand how exercise exacerbates this condition by activating inflammatory pathways in heart cells. Researchers will use advanced genetic techniques in mouse models to explore the mechanisms behind this disease and test whether anti-inflammatory treatments can mitigate its effects. The findings could lead to new strategies for preventing dangerous heart events in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that significantly reduce the risk of sudden cardiac events in patients with arrhythmogenic cardiomyopathy.
How similar studies have gone: Previous research has shown promising results in understanding the role of inflammation in heart diseases, suggesting that this approach could lead to meaningful advancements.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Saffitz, Jeffrey E — Beth Israel Deaconess Medical Center
- Study coordinator: Saffitz, Jeffrey E
Related research
Other NIH-funded projects on the same topics.
-
Global bromocriptine trial for postpartum cardiomyopathy
A large international study will test whether adding bromocriptine to standard heart failure treatment helps new mothers with peripartum cardiomyopathy.
-
Global Bromocriptine Add-on for Postpartum Heart Failure (GLOBal PPCM)
A large international study will test whether adding the dopamine agonist bromocriptine to standard heart failure care helps postpartum women with a specific heart condition.
-
Global Bromocriptine Trial for Postpartum Heart Failure (GLOBal PPCM)
A large international study will test whether adding bromocriptine to standard heart-failure care helps women with postpartum cardiomyopathy.
-
Bromocriptine as add-on therapy for postpartum cardiomyopathy across multiple sites
A large international study will test whether adding bromocriptine to standard heart failure treatment helps new mothers with postpartum cardiomyopathy.
-
Global bromocriptine trial to help postpartum heart failure patients
A large international trial tests whether adding bromocriptine to standard heart failure treatment improves outcomes for new mothers with a specific pregnancy-related heart condition.
-
Global Bromocriptine Trial to Help Postpartum Heart Failure
A large international study will test whether adding bromocriptine to standard heart failure treatment helps women with postpartum cardiomyopathy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.