How inflammation affects bone healing and regeneration
Epigenetic Regulation of Bone Regeneration in Inflammatory Disease
This study looks at how inflammation affects the healing of broken bones, especially for people with inflammatory diseases, and aims to find ways to help improve recovery by understanding the role of certain proteins and genes in bone repair.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10889023 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which inflammation impacts the healing process of bone fractures, particularly in patients with inflammatory diseases. It focuses on the role of specific proteins and genes that regulate bone regeneration, aiming to understand how chronic inflammation can hinder recovery. By studying the behavior of certain cells involved in bone repair, the research seeks to identify potential therapeutic targets that could enhance healing in affected individuals. The approach includes both laboratory experiments and analysis of biological samples from patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include elderly individuals and patients with conditions such as rheumatoid arthritis, diabetes, or those experiencing chronic inflammation.
Not a fit: Patients without inflammatory conditions or those with healthy bone healing processes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve bone healing in patients suffering from inflammatory conditions.
How similar studies have performed: Other research has shown promising results in understanding the role of inflammation in bone healing, suggesting that this approach could lead to significant advancements.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Shen, Jie — Washington University
- Study coordinator: Shen, Jie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.