How inflammation affects bone healing and regeneration
Official title: Epigenetic Regulation of Bone Regeneration in Inflammatory Disease
Funded at Washington University · NIH-10889023 · Data updated 2026-11-12
This study looks at how inflammation affects the healing of broken bones, especially for people with inflammatory diseases, and aims to find ways to help improve recovery by understanding the role of certain proteins and genes in bone repair.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | July 8, 2019 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $516,781 |
| NIH project number | 5R01AR075860-05 |
| Project ID | NIH-10889023 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include elderly individuals and patients with conditions such as rheumatoid arthritis, diabetes, or those experiencing chronic inflammation.
✕Less likely to help
Patients without inflammatory conditions or those with healthy bone healing processes may not benefit from this research.
What this research studies
This research investigates the mechanisms by which inflammation impacts the healing process of bone fractures, particularly in patients with inflammatory diseases. It focuses on the role of specific proteins and genes that regulate bone regeneration, aiming to understand how chronic inflammation can hinder recovery. By studying the behavior of certain cells involved in bone repair, the research seeks to identify potential therapeutic targets that could enhance healing in affected individuals. The approach includes both laboratory experiments and analysis of biological samples from patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve bone healing in patients suffering from inflammatory conditions.
How similar studies have gone: Other research has shown promising results in understanding the role of inflammation in bone healing, suggesting that this approach could lead to significant advancements.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Shen, Jie — Washington University
- Study coordinator: Shen, Jie
Related research
Other NIH-funded projects on the same topics.
-
Glutathionylated products from lipid oxidation in eye disease
This project studies how lipid-oxidation products in the eye might drive age-related macular degeneration and related conditions, by looking at molecules that behave like inflammatory signals.
-
Inflammation risks in clonal hematopoiesis and cancer
This grant studies how clonal hematopoiesis may drive inflammatory diseases and helps predict who is at risk so doctors can prevent complications in people with blood cancers.
-
IgE responses to alpha-gal and how they relate to allergic disease
This project studies why some people develop allergic reactions to mammal products due to alpha-gal and what this means for diagnosing and managing the condition.
-
Alpha‑gal allergy: delayed reactions to red meat and mammal‑derived products
Researchers are looking at why some adults get delayed allergic reactions hours after eating mammal products (alpha‑gal) and how to better diagnose and manage them.
-
A signaling switch that keeps inflammation in check in lupus-like disease
Researchers study how a signaling module in immune cells controls inflammation linked to lupus by examining proteins that turn inflammation on and off.
-
Gut bacteria and steroid hormones in inflammatory bowel disease
A study in people and mice looks at how gut bacteria may change steroids that reduce inflammation in inflammatory bowel disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.