Understanding how clonal hematopoiesis affects inflammatory diseases
Official title: Inflammatory Disease Associations in Clonal Hematopoiesis
Funded at Dana-Farber Cancer Inst · NIH-10982741 · Data updated 2026-11-12
This study is looking at how a condition called clonal hematopoiesis, where certain blood cells grow due to mutations, might be connected to inflammatory diseases like arthritis, and it aims to help predict who might be at risk for these issues and how different treatments can affect symptoms.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $165,080 |
| NIH project number | 1K08HL171883-01A1 |
| Project ID | NIH-10982741 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with clonal hematopoiesis or clonal cytopenia of uncertain significance.
✕Less likely to help
Patients without clonal hematopoiesis or those with unrelated inflammatory conditions may not benefit from this research.
What this research studies
This research investigates clonal hematopoiesis (CH), a condition where a population of blood cells expands due to mutations, and its links to inflammatory diseases. The study aims to identify the relationship between CH and various inflammatory conditions, including rheumatologic diseases, and to develop a statistical model that predicts individual risk for these diseases. By analyzing patients with clonal cytopenia of uncertain significance who have received specific therapies, the research seeks to uncover how treatment influences inflammatory symptoms. This comprehensive approach aims to improve risk assessment and management strategies for patients with CH.
Why it matters
Potential benefit: If successful, this research could lead to better risk assessment and management strategies for patients with clonal hematopoiesis, potentially reducing the incidence of inflammatory diseases.
How similar studies have gone: Previous research has shown promising results in understanding the links between clonal hematopoiesis and various health outcomes, indicating that this approach has potential for success.
Where this research is happening
-
Dana-Farber Cancer Inst
Boston, United States Active
Researchers
- Principal investigator: Weeks, Lachelle Dawn — Dana-Farber Cancer Inst
- Study coordinator: Weeks, Lachelle Dawn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.