Investigating genetic variants affecting inflammation regulation
Identifying the Effect of Genetic Variants on Specialized Pro-resolving Mediators and Their Association With Chronic Inflammatory Conditions
This study is trying to see if certain genetic changes in South Asian people affect how their bodies handle inflammation and could lead to chronic inflammatory diseases.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Queen Mary University of London Academic / other |
| Locations | 1 site (London) |
| Trial ID | NCT04698291 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify genetic variants in specialized pro-resolving mediator (SPM)-related genes within a South Asian population. It will assess how these genetic mutations influence the function of enzymes and receptors involved in inflammation regulation. By analyzing data from the Gene & Health program and the UK Biobank, the study seeks to link specific genetic polymorphisms to altered immune responses and the incidence of chronic inflammatory diseases. Blood samples will be collected from participants with and without relevant genetic mutations to evaluate differences in lipid mediator profiles.
Who should consider this trial
Good fit: Ideal candidates are current volunteers of the Gene & Health program who have undergone genome sequencing and have relevant genetic mutations or are controls without these mutations.
Not a fit: Patients with significant genetically inherited conditions or those recovering from surgery may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new insights into the genetic factors influencing inflammatory diseases, potentially guiding personalized treatment strategies.
How similar studies have performed: Other studies have shown success in linking genetic variants to inflammatory responses, making this approach promising yet still exploring specific genetic impacts.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Current volunteer of the Genes \& Health program with (test) or without (control) relevant genetic mutations. Genes \& Health is a huge long-term study of 100,000 people of Bangladeshi and Pakistani origin focuses to link genes with health records and to study disease and treatments. When a volunteer participates in this program, they agree to the possibility to be invited for further studies. Gene \& Health program invites volunteers to take part in two regions of the UK: East London and Bradford. Exclusion Criteria: 1. Volunteer that has not had their genome sequenced after taking part in Stage 1 of Genes \& Health program. 2. Volunteer with significant genetically inherited conditions. 3. Any abnormality or pre-existing disease which, in the opinion of the investigator, might either expose the subject to risk, or influence the validity of the results. 4. Volunteer that went under surgery and are recovering. 5. Participation in a clinical study of a new chemical entity, biological product or a prescription medicine, or loss of more than 400 mL blood, within the previous 3 months. 6. Presence or history of drug or alcohol abuse.
Where this trial is running
London
- Queen Mary University of London — London, United Kingdom (Recruiting)
Study contacts
- Study coordinator: Esteban A Gomez Cifuentes, PhD student
- Email: e.a.g.c.cifuentes@qmul.ac.uk
- Phone: +447741093970
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.