Investigating genetic variants affecting inflammation regulation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify genetic variants in specialized pro-resolving mediator (SPM)-related genes within a South Asian population. It will assess how these genetic mutations influence the function of enzymes and receptors involved in inflammation regulation. By analyzing data from the Gene & Health program and the UK Biobank, the study seeks to link specific genetic polymorphisms to altered immune responses and the incidence of chronic inflammatory diseases. Blood samples will be collected from participants with and without relevant genetic mutations to evaluate differences in lipid mediator profiles.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Current volunteer of the Genes \& Health program with (test) or without (control) relevant genetic mutations. Genes \& Health is a huge long-term study of 100,000 people of Bangladeshi and Pakistani origin focuses to link genes with health records and to study disease and treatments. When a volunteer participates in this program, they agree to the possibility to be invited for further studies. Gene \& Health program invites volunteers to take part in two regions of the UK: East London and Bradford.

Exclusion Criteria:

1. Volunteer that has not had their genome sequenced after taking part in Stage 1 of Genes \& Health program.
2. Volunteer with significant genetically inherited conditions.
3. Any abnormality or pre-existing disease which, in the opinion of the investigator, might either expose the subject to risk, or influence the validity of the results.
4. Volunteer that went under surgery and are recovering.
5. Participation in a clinical study of a new chemical entity, biological product or a prescription medicine, or loss of more than 400 mL blood, within the previous 3 months.
6. Presence or history of drug or alcohol abuse.

Where it's running

• Queen Mary University of London
  London, United Kingdom Recruiting

Study contacts

• Study coordinator: Esteban A Gomez Cifuentes, PhD student
• Email: e.a.g.c.cifuentes@qmul.ac.uk
• Phone: +447741093970

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.