Understanding how immune cells respond to bacterial infections
Official title: Innate Immune signal transduction specificity in inflammatory disease
Funded at Case Western Reserve University · NIH-11042711 · Data updated 2026-11-12
This study is looking at how a protein in your immune cells helps them fight off bacterial infections, and it's for anyone interested in finding new ways to manage conditions caused by too much inflammation, like allergies or autoimmune diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | May 1, 2021 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $362,250 |
| NIH project number | 5R35GM141603-04 |
| Project ID | NIH-11042711 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with inflammatory diseases linked to bacterial infections or those experiencing immune system dysregulation.
✕Less likely to help
Patients with non-inflammatory conditions or those not affected by bacterial infections may not benefit from this research.
What this research studies
This research investigates how a specific protein complex in immune cells helps them recognize and respond to bacterial infections. By studying the NOD2:RIPK2 complex, the researchers aim to understand how to balance the immune response—too little can lead to infections, while too much can cause inflammatory diseases. They are developing drugs to inhibit this complex when it becomes overly active, which could help manage conditions related to excessive inflammation. The research involves advanced techniques like mass spectrometry to identify how this signaling pathway works.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from inflammatory diseases caused by bacterial infections.
How similar studies have gone: Other research has shown promise in targeting immune signaling pathways, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Abbott, Derek W — Case Western Reserve University
- Study coordinator: Abbott, Derek W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.