Exploring Molecules Linked to Eye Inflammation and Retinal Damage
Official title: Administrative Supplement: Glutathionylated Products of Radical-Induced Lipid Oxidation in Inflammatory Disease
Funded at Case Western Reserve University · NIH-11321907 · Data updated 2026-11-12
This project aims to understand how certain molecules, called pseudo leukotrienes, contribute to eye conditions like age-related macular degeneration by studying them in the retina.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $136,051 |
| NIH project number | 3R01EY034075-02S1 |
| Project ID | NIH-11321907 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with retinal diseases, such as age-related macular degeneration, may eventually benefit from the knowledge gained from this fundamental research.
✕Less likely to help
Patients without retinal conditions or those whose conditions are not related to lipid oxidation may not directly benefit from this specific line of research.
What this research studies
Our eyes can experience damage from processes like lipid oxidation, which creates specific molecules called pseudo leukotrienes (øLTs). These øLTs are similar to other inflammatory molecules and are found in the human retina, especially after oxidative stress. We believe these øLTs might contribute to eye conditions such as age-related macular degeneration. To learn more, we are using advanced equipment to measure these molecules and observe their effects in models of retinal degeneration. This work helps us understand how these molecules affect eye health and could guide future treatments.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of retinal diseases and potentially new ways to prevent or treat conditions like age-related macular degeneration.
How similar studies have gone: While the role of similar inflammatory molecules (leukotrienes) in retinal pathology is known, the specific contribution of pseudo leukotrienes (øLTs) is a novel area of investigation.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Salomon, Robert Gerd — Case Western Reserve University
- Study coordinator: Salomon, Robert Gerd
Related research
Other NIH-funded projects on the same topics.
-
Glutathionylated products from lipid oxidation in eye disease
This project studies how lipid-oxidation products in the eye might drive age-related macular degeneration and related conditions, by looking at molecules that behave like inflammatory signals.
-
Inflammation risks in clonal hematopoiesis and cancer
This grant studies how clonal hematopoiesis may drive inflammatory diseases and helps predict who is at risk so doctors can prevent complications in people with blood cancers.
-
IgE responses to alpha-gal and how they relate to allergic disease
This project studies why some people develop allergic reactions to mammal products due to alpha-gal and what this means for diagnosing and managing the condition.
-
Alpha‑gal allergy: delayed reactions to red meat and mammal‑derived products
Researchers are looking at why some adults get delayed allergic reactions hours after eating mammal products (alpha‑gal) and how to better diagnose and manage them.
-
A signaling switch that keeps inflammation in check in lupus-like disease
Researchers study how a signaling module in immune cells controls inflammation linked to lupus by examining proteins that turn inflammation on and off.
-
Gut bacteria and steroid hormones in inflammatory bowel disease
A study in people and mice looks at how gut bacteria may change steroids that reduce inflammation in inflammatory bowel disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.