Condition

Infective Endocarditis clinical trials and research

• 14Clinical trials
• 6NIH research projects
• 9Countries

Newest Infective Endocarditis clinical trials

All recruiting trials (14)

• Al[18F]F-NOTA-folate PET imaging in suspected cardiac sarcoidosis and infective endocarditis

  This diagnostic test uses a folate-based PET tracer to see if it can help identify inflammation or infection in the heart for people with suspected cardiac sarcoidosis or infective endocarditis.

  Recruiting Turku University Hospital · Turku · NCT07814222

• Etiologic Diagnosis Algorithm in Infective Endocarditis

  Aiming to see if a combined culture and molecular testing approach can help doctors choose the right antibiotics faster for adults with infective endocarditis.

  Recruiting at 2 sites I.M. Sechenov First Moscow State Medical University · Moscow and 2 other locations · NCT07682389

• Rifampin-free therapy vs rifampin-containing therapy for staphylococcal prosthetic valve endocarditis

  This study tests whether a rifampin-free antibiotic regimen can be as effective as a rifampin-containing regimen for adults with staphylococcal prosthetic valve endocarditis.

  Recruiting at 29 sites Phase 3 Nantes University Hospital · Aix-les-Bains and 30 other locations · NCT07345325

• Improving health and quality of life for patients recovering from infective endocarditis through cardiac rehabilitation

  This study is testing if joining a cardiac rehabilitation program can help people recovering from infective endocarditis feel healthier and improve their quality of life.

  Recruiting Region Halland · Halmstad, Halland County · NCT06704048

• Echocardiography versus no echocardiography for Staphylococcus aureus bloodstream infection with VIRSTA score <3

  This trial tests whether it is safe to skip routine echocardiography in adults hospitalized with Staphylococcus aureus bloodstream infection who have a VIRSTA score under 3.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06457386

• Barts Endocarditis Registry

  This registry collects health, imaging, microbiology, treatment, and outcome information from adults with infective endocarditis seen at Barts Heart Centre to learn which approaches work best.

  Recruiting Queen Mary University of London · London · NCT06434012

• Registry and biobank for infectious diseases

  This study is creating a database and collection of samples from patients with different infectious diseases to see how these illnesses affect treatment outcomes and to learn more about managing them.

  Recruiting IRCCS San Raffaele · Milan · NCT06418048

• Comparing imaging techniques for oral health in patients with infective endocarditis

  This study is testing if a special type of dental scan called Cone Beam Computed Tomography can find oral infections better than a regular dental X-ray in patients with infective endocarditis to help improve their oral health.

  Recruiting at 10 sites Nantes University Hospital · Bordeaux and 9 other locations · NCT06269679

• Understanding the prognosis and biomarkers of infective endocarditis

  This study is trying to learn more about how infective endocarditis progresses and what factors affect it by looking at patients and their biomarkers to improve diagnosis and treatment.

  Recruiting First Affiliated Hospital Xi'an Jiaotong University · Xi'an, Shaanxi · NCT05965362

• Improving oral hygiene to reduce risk of infective endocarditis

  This study tests if better oral hygiene, through dental cleaning and education, can help reduce bacteria in the blood for people at risk of infective endocarditis.

  Recruiting at 3 sites Wake Forest University Health Sciences · Boston, Massachusetts and 5 other locations · NCT05721781

• Observational study of patients with infective endocarditis

  This study is collecting health information from patients with infective endocarditis to see how to better treat and manage the condition over time.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT04992923

• Evaluating the role of FDG-PET/CT in managing infective endocarditis

  This study is testing whether FDG-PET/CT imaging can help doctors make better treatment decisions for adults suspected of having infective endocarditis.

  Recruiting at 2 sites Montreal Heart Institute · Montreal, Quebec and 5 other locations · NCT04792281

• Understanding how beta-lactam antibiotics work in patients with infective endocarditis

  This study is trying to see how beta-lactam antibiotics work in patients with infective endocarditis and how different factors like age and weight might affect their effectiveness.

  Recruiting at 2 sites Uppsala University · Gothenburg and 3 other locations · NCT04647331

• National database for infective endocarditis in France

  This study is creating a national database to collect and analyze information about patients with infective endocarditis in France to better understand their treatment and outcomes.

  Recruiting Central Hospital, Nancy, France · Vandœuvre-lès-Nancy · NCT03272724

NIH-funded research (6)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Co-treated care for substance use and heart infection at UVMMC

  A hospital-based project aims to improve how doctors and teams treat people with both substance use disorder and infective endocarditis during their hospital stay.

  NIH research University of Vermont & St Agric College · Burlington, United States · NIH-11599499

• Non-surgical dental care and oral hygiene to lower risk of infective endocarditis

  This project tests whether professional dental cleanings plus clear home oral hygiene instruction can reduce the mouth bacteria that enter the bloodstream and may cause heart valve infections in people with certain heart conditions.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11285146

• Understanding the risk factors for heart infections caused by Enterococcus faecalis

  This study is looking at how bacteria and your health information work together to help us understand what might increase the risk of a serious heart infection called enterococcal infective endocarditis, so we can find better ways to treat and care for patients like you.

  NIH research Broad Institute, INC. · Cambridge, United States · NIH-11136217

• Improving oral hygiene to lower the risk of heart infections from bacteria

  This study is looking at whether improving your oral hygiene, like getting professional dental cleanings and learning better brushing techniques, can help lower the chances of getting a serious heart infection called infective endocarditis, especially for people who already have heart conditions.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11039835

• Understanding outcomes and treatment preferences for heart infections related to drug use

  This study is looking at what happens to people in North Carolina after they leave the hospital for a serious heart infection caused by drug use, focusing on their experiences, challenges like overdoses or returning to the hospital, and what kind of treatment they prefer to help them with their ongoing struggles.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-10810845

• Understanding how certain bacteria attach to heart tissue during infections

  This study is looking at how certain bacteria stick to blood cells in the heart, which can help us understand and find better ways to prevent and treat heart infections, especially for people who are at risk.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-10748408

Related topics

Quick answers

How many Infective Endocarditis clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in France (5 trials), Sweden (2 trials), Finland (1 trial), Italy (1 trial), Russia (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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