Understanding how beta-lactam antibiotics work in patients with infective endocarditis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to investigate the pharmacokinetics of beta-lactam antibiotics in patients diagnosed with infective endocarditis. It will collect data on antibiotic concentrations, patient characteristics, and treatment outcomes to understand how factors like age, body weight, and renal function influence drug behavior in the body. A mathematical model will be developed to identify which patient factors affect drug pharmacokinetics, potentially leading to improved treatment strategies. The study will involve prospective inclusion of patients from multiple university hospitals in Sweden.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Verified or suspected left or right sided endocarditis in native or prosthetic valve
* Intravenous antibiotic therapy with either ampicillin, penicillin G, cefotaxime or cloxacillin
* Signed informed consent to participate in study

Exclusion Criteria:

* \<18 years of age
* Ongoing dialysis

Where it's running

• Skåne University Hospital
  Lund, Sweden Recruiting
• Uppsala University Hospital
  Uppsala, Sweden Recruiting
• Sahlgrenska University Hospital
  Gothenburg, Sweden Active not recruiting
• Karolinska University Hospital
  Stockholm, Sweden Not yet recruiting

Study contacts

• Principal investigator: Thomas Tängdén, MD, Phd — Uppsala University Hospital
• Study coordinator: Thomas Tängdén, MD, Phd
• Email: thomas.grenholm.tangden@medsci.uu.se
• Phone: +46708370323

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.