Observational study of patients with infective endocarditis
Official title: Prospective Cohort Study of Patients With Infective Endocarditis Admitted at Cardiology Institute of Pitié-Salpêtrière Hospital
Run by Assistance Publique - Hôpitaux de Paris · NCT04992923 · Data updated 2026-11-12
This study is collecting health information from patients with infective endocarditis to see how to better treat and manage the condition over time.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 700 (estimated) |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Paris) |
| Status | Recruiting |
| Started | September 15, 2020 |
| Main results expected | September 2040 |
| Study ends | March 2041 |
| Registry record updated | November 21, 2025 |
| Trial ID | NCT04992923 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients with a confirmed diagnosis of infective endocarditis according to European Society of Cardiology criteria.
✕Probably not a fit
Patients who oppose participation in the study will not benefit from the findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to gather comprehensive clinical data from patients diagnosed with infective endocarditis (IE) at the Pitié-Salpêtrière Hospital. It will involve collecting demographic, clinical, laboratory, and imaging data at the time of diagnosis and during follow-up, which can extend up to 10 years. The goal is to improve the management and prognosis of IE by establishing a large prospective cohort, as current guidelines are primarily based on expert consensus rather than robust data.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies and better prognostic outcomes for patients with infective endocarditis.
How similar studies have gone: While there is limited prospective data on infective endocarditis, this approach aims to fill a significant gap in the existing literature, suggesting it is a novel and necessary endeavor.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with confirmed IE according to European Society of Cardiology criteria Exclusion Criteria: * Opposition of the patient to participate
Where it's running
-
APHP Pitié-Salpêtrière Hospital, Department of Cardiology
Paris, France Recruiting
Study contacts
- Principal investigator: Nadjib Hammoudi, MD, PhD — Pitié-Salpêtrière Hospital
- Study coordinator: Nadjib Hammoudi, MD, PhD
- Email: nadjib.hammoudi@aphp.fr
- Phone: +33 142165535
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Al[18F]F-NOTA-folate PET imaging in suspected cardiac sarcoidosis and infective endocarditis
This diagnostic test uses a folate-based PET tracer to see if it can help identify inflammation or infection in the heart for people with suspected cardiac sarcoidosis or infective endocarditis.
-
Etiologic Diagnosis Algorithm in Infective Endocarditis
Aiming to see if a combined culture and molecular testing approach can help doctors choose the right antibiotics faster for adults with infective endocarditis.
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This study tests whether a rifampin-free antibiotic regimen can be as effective as a rifampin-containing regimen for adults with staphylococcal prosthetic valve endocarditis.
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Improving health and quality of life for patients recovering from infective endocarditis through cardiac rehabilitation
This study is testing if joining a cardiac rehabilitation program can help people recovering from infective endocarditis feel healthier and improve their quality of life.
-
Echocardiography versus no echocardiography for Staphylococcus aureus bloodstream infection with VIRSTA score <3
This trial tests whether it is safe to skip routine echocardiography in adults hospitalized with Staphylococcus aureus bloodstream infection who have a VIRSTA score under 3.
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Barts Endocarditis Registry
This registry collects health, imaging, microbiology, treatment, and outcome information from adults with infective endocarditis seen at Barts Heart Centre to learn which approaches work best.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.