Understanding the risk factors for heart infections caused by Enterococcus faecalis
Deep integration of multi-omics and patient health data to clarify risk factors of enterococcal infective endocarditis
This study is looking at how bacteria and your health information work together to help us understand what might increase the risk of a serious heart infection called enterococcal infective endocarditis, so we can find better ways to treat and care for patients like you.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-11136217 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between bacterial genetics and patient health data to better understand the risk factors associated with enterococcal infective endocarditis. By analyzing a unique dataset of over 1,189 cases collected over 15 years, the study aims to identify key bacterial and host factors that contribute to the development of this serious heart infection. The approach includes integrating multi-omics data, which encompasses genomics and proteomics, to provide a comprehensive view of the disease. This could lead to improved healthcare decisions and treatment options for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of enterococcal bacteremia or those who have prosthetic heart valves.
Not a fit: Patients without a history of enterococcal infections or those who do not have heart conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better identification of at-risk patients and more effective treatment strategies for enterococcal infective endocarditis.
How similar studies have performed: Previous studies have shown promise in understanding bacterial infections through multi-omics approaches, suggesting that this research could build on established methodologies.
Where this research is happening
Cambridge, United States
- Broad Institute, INC. — Cambridge, United States (Active)
Researchers
- Principal investigator: Smith, Joshua Thomas — Broad Institute, INC.
- Study coordinator: Smith, Joshua Thomas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.