Understanding the risk factors for heart infections caused by Enterococcus faecalis
Official title: Deep integration of multi-omics and patient health data to clarify risk factors of enterococcal infective endocarditis
Funded at Broad Institute, INC. · NIH-11136217 · Data updated 2026-11-12
This study is looking at how bacteria and your health information work together to help us understand what might increase the risk of a serious heart infection called enterococcal infective endocarditis, so we can find better ways to treat and care for patients like you.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $79,282 |
| NIH project number | 5F32AI179151-02 |
| Project ID | NIH-11136217 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of enterococcal bacteremia or those who have prosthetic heart valves.
✕Less likely to help
Patients without a history of enterococcal infections or those who do not have heart conditions may not benefit from this research.
What this research studies
This research investigates the complex interactions between bacterial genetics and patient health data to better understand the risk factors associated with enterococcal infective endocarditis. By analyzing a unique dataset of over 1,189 cases collected over 15 years, the study aims to identify key bacterial and host factors that contribute to the development of this serious heart infection. The approach includes integrating multi-omics data, which encompasses genomics and proteomics, to provide a comprehensive view of the disease. This could lead to improved healthcare decisions and treatment options for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to better identification of at-risk patients and more effective treatment strategies for enterococcal infective endocarditis.
How similar studies have gone: Previous studies have shown promise in understanding bacterial infections through multi-omics approaches, suggesting that this research could build on established methodologies.
Where this research is happening
-
Broad Institute, INC.
Cambridge, United States Active
Researchers
- Principal investigator: Smith, Joshua Thomas — Broad Institute, INC.
- Study coordinator: Smith, Joshua Thomas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.