Echocardiography versus no echocardiography for Staphylococcus aureus bloodstream infection with VIRSTA score <3

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults hospitalized with at least one positive blood culture for Staphylococcus aureus and a VIRSTA score <3 are assigned to either routine echocardiography or a no-echocardiography strategy. The trial uses negative follow-up blood cultures at 48 hours and excludes patients who already had echocardiography, have prosthetic valves, or other contraindications. The primary endpoints are mortality and relapse of Staphylococcus aureus bacteremia measured at 90 days to capture delayed diagnoses of infective endocarditis or inadequate treatment. The design aims to determine whether withholding echocardiography in low-VIRSTA patients reduces unnecessary testing and conserves resources without harming patients.

Why it matters

Who can join: the full rules

Inclusion criteria

* Volunteers over 18 years of age;
* Hospitalized with at least one blood culture positive for Staphylococcus aureus;
* At the time of inclusion, negative control blood culture performed 48 hours after the first Staphylococcus aureus blood culture collection;
* VIRSTA score \< 3; Exclusion criteria
* Patient with catheter colonization without SAB, defined as positive blood cultures only through vascular access device specimen;
* Patient referred to the hospital for the management of IE;
* Contra indication to transthoracic echocardiography (TTE);
* Echocardiography already performed before inclusion (TTE or TEE) for the current SAB;
* Pregnancy;
* Patient under guardianship or trusteeship.
* Absence of written informed consent from the patient
* No affiliation to social security (beneficiary or assignee)
* Subject already involved in another interventional clinical research for which echocardiography must be done"

Where it's running

• Bichat Claude Bernard Hospital
  Paris, France Recruiting

Study contacts

• Principal investigator: Xavier Duval — Assistance Publique - Hôpitaux de Paris
• Study coordinator: Xavier Duval
• Email: xavier.duval@aphp.fr
• Phone: 01 40 25 71 35

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.