Comparing imaging techniques for oral health in patients with infective endocarditis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of Cone Beam Computed Tomography (CBCT) compared to traditional Orthopantomogram (OPT) in detecting Oral Infectious Foci (OIF) in patients hospitalized for infective endocarditis (IE). Given that streptococci of oral origin are a common cause of IE, the study will assess whether the enhanced sensitivity of CBCT can lead to better oral health outcomes and potentially reduce new episodes of IE. Patients will be randomly assigned to receive either imaging technique during their hospitalization, and their oral health status will be monitored over a 12-month period.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients hospitalized or recently hospitalized for definite IE according to the 2015 ESC classification, naive patients for dental examination and imaging, whatever the IE responsible microorganism;
2. Patients with a stable clinical state, meaning stabilized IE patients out of the critical phase, compatible with the performance of an OPT and a CBCT;
3. Patients whose life expectancy is expected to be longer than 6 months;
4. Patients who agree to visit the dental department of the hospital to carry out OIF eradication or at his/her personal dentist;
5. Patients over 18 years old;
6. Patients affiliated to a Social Security or a health insurance scheme;
7. Patients who have given informed consent to participate to the study.

Exclusion Criteria:

1. OPT or CBCT already performed before the inclusion of the patients in the study and available for the investigator during the patient's hospitalization.
2. Medical contraindications to perform OPT or CBCT imaging;
3. Absence of microbiologic identification of the IE responsible microorganism;
4. Pregnant or breastfeeding women;
5. Patients unable to give informed consent to participate to the study (under trusteeship, guardianship and legal protection).

Where it's running

• CHU Bordeaux - Site Pellegrin
  Bordeaux, France Recruiting
• CHU Clermont-Ferrand
  Clermont-Ferrand, France Recruiting
• CHU Grenoble
  Grenoble, France Recruiting
• Hcl
  Lyon, France Recruiting
• Aphm
  Marseille, France Recruiting
• CHRU Nancy
  Nancy, France Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.