Clinical trial Recruiting at 1 site Observational Ages 16 and up

Barts Endocarditis Registry

Official title: Barts Endocarditis Research Registry

Run by Queen Mary University of London · NCT06434012 · Data updated 2026-11-12

This registry collects health, imaging, microbiology, treatment, and outcome information from adults with infective endocarditis seen at Barts Heart Centre to learn which approaches work best.

Quick facts

Study typeObservational
Ages16 Years and up
SexAll
Enrollment1000 (estimated)
SponsorQueen Mary University of London
Academic / other
Locations1 site (London)
StatusRecruiting
StartedApril 24, 2019
Main results expectedApril 24, 2029
Study endsApril 30, 2029
Registry record updatedJuly 17, 2026
Trial IDNCT06434012 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults (16 years and older) admitted to or attending outpatient services at Barts Heart Centre with confirmed, possible, or device-related infective endocarditis who can give informed consent are ideal candidates.

Probably not a fit

Patients under 16, those with pacemaker pocket infection without lead or valve involvement, or patients who refuse consent would not be included and therefore would not directly benefit from this registry.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational registry enrolling patients aged 16 and over with confirmed or suspected infective endocarditis, including device-related cases, who are treated or followed at Barts Heart Centre. Clinical, demographic, microbiological, imaging, surgical, and outcome data will be recorded and stored to define the local patient cohort. The registry is intended to track guideline implementation, document diagnostic and treatment patterns, and provide a baseline for future genomic and interventional trials. Data collection will support quality improvement and enable planned downstream research projects.

Why it matters

Potential benefit: If successful, the registry could improve diagnosis and management of infective endocarditis at the centre and help design future trials that reduce complications and mortality.

How similar studies have gone: Hospital-based endocarditis registries have previously informed guideline uptake and trial design and improved local understanding of disease patterns, although mortality from endocarditis remains substantial.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* • Patients aged 16 and over (Patients under 16 years of age are not admitted to Barts Heart Centre)

  * Patients admitted to Barts Heart Centre with confirmed Endocarditis (see above)
  * Patients attending outpatients with confirmed/suspected Endocarditis
  * Patients with possible IE who complete treatment for endocarditis
  * Patients with cardiac device related Endocarditis
  * Patients with the ability to provide informed consent

Exclusion Criteria:

* • Patients with pacemaker pocket infection with no evidence of pacemaker lead or valve infection

  * Patients who refuse consent to be included in the research database
  * Patients with "rejected" endocarditis

Where it's running

  • St Bartholomews Hospital
    London, United Kingdom
    Recruiting

Study contacts

  • Principal investigator: Simon Woldman, MSc — St Bartholomews Hospital
  • Study coordinator: Innocent Bvekerwa, MSc
  • Email: i.bvekerwa@nhs.net
  • Phone: 07852209005

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.