Barts Endocarditis Registry
Official title: Barts Endocarditis Research Registry
Run by Queen Mary University of London · NCT06434012 · Data updated 2026-11-12
This registry collects health, imaging, microbiology, treatment, and outcome information from adults with infective endocarditis seen at Barts Heart Centre to learn which approaches work best.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 16 Years and up |
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | Queen Mary University of London Academic / other |
| Locations | 1 site (London) |
| Status | Recruiting |
| Started | April 24, 2019 |
| Main results expected | April 24, 2029 |
| Study ends | April 30, 2029 |
| Registry record updated | July 17, 2026 |
| Trial ID | NCT06434012 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (16 years and older) admitted to or attending outpatient services at Barts Heart Centre with confirmed, possible, or device-related infective endocarditis who can give informed consent are ideal candidates.
✕Probably not a fit
Patients under 16, those with pacemaker pocket infection without lead or valve involvement, or patients who refuse consent would not be included and therefore would not directly benefit from this registry.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational registry enrolling patients aged 16 and over with confirmed or suspected infective endocarditis, including device-related cases, who are treated or followed at Barts Heart Centre. Clinical, demographic, microbiological, imaging, surgical, and outcome data will be recorded and stored to define the local patient cohort. The registry is intended to track guideline implementation, document diagnostic and treatment patterns, and provide a baseline for future genomic and interventional trials. Data collection will support quality improvement and enable planned downstream research projects.
Why it matters
Potential benefit: If successful, the registry could improve diagnosis and management of infective endocarditis at the centre and help design future trials that reduce complications and mortality.
How similar studies have gone: Hospital-based endocarditis registries have previously informed guideline uptake and trial design and improved local understanding of disease patterns, although mortality from endocarditis remains substantial.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * • Patients aged 16 and over (Patients under 16 years of age are not admitted to Barts Heart Centre) * Patients admitted to Barts Heart Centre with confirmed Endocarditis (see above) * Patients attending outpatients with confirmed/suspected Endocarditis * Patients with possible IE who complete treatment for endocarditis * Patients with cardiac device related Endocarditis * Patients with the ability to provide informed consent Exclusion Criteria: * • Patients with pacemaker pocket infection with no evidence of pacemaker lead or valve infection * Patients who refuse consent to be included in the research database * Patients with "rejected" endocarditis
Where it's running
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St Bartholomews Hospital
London, United Kingdom Recruiting
Study contacts
- Principal investigator: Simon Woldman, MSc — St Bartholomews Hospital
- Study coordinator: Innocent Bvekerwa, MSc
- Email: i.bvekerwa@nhs.net
- Phone: 07852209005
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Etiologic Diagnosis Algorithm in Infective Endocarditis
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This study tests whether a rifampin-free antibiotic regimen can be as effective as a rifampin-containing regimen for adults with staphylococcal prosthetic valve endocarditis.
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Using bacteriophages with antibiotics to treat infective endocarditis
This study is testing whether using a special virus called bacteriophages along with antibiotics can help people with a serious heart infection called infective endocarditis.
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Improving health and quality of life for patients recovering from infective endocarditis through cardiac rehabilitation
This study is testing if joining a cardiac rehabilitation program can help people recovering from infective endocarditis feel healthier and improve their quality of life.
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Echocardiography versus no echocardiography for Staphylococcus aureus bloodstream infection with VIRSTA score <3
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.