Understanding the prognosis and biomarkers of infective endocarditis
Official title: Prognosis of Patients With Infective Endocarditis and Risk Stratification Value of Biomarkers (ENDEAVOR): a National Multi-center, Retrospective-prospective, Cohort Study Initiated by the Investigators
Run by First Affiliated Hospital Xi'an Jiaotong University · NCT05965362 · Data updated 2026-11-12
This study is trying to learn more about how infective endocarditis progresses and what factors affect it by looking at patients and their biomarkers to improve diagnosis and treatment.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 2000 (estimated) |
| Sponsor | First Affiliated Hospital Xi'an Jiaotong University Academic / other |
| Locations | 1 site (Xi'an, Shaanxi) |
| Status | Recruiting |
| Started | May 9, 2024 |
| Main results expected | December 31, 2028 |
| Study ends | December 31, 2028 |
| Registry record updated | July 12, 2024 |
| Trial ID | NCT05965362 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients with clinically confirmed infective endocarditis.
✕Probably not a fit
Patients who refuse to sign the informed consent form or have serious systemic diseases that prevent them from tolerating biological sample acquisition may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to establish a clinical cohort of patients with infective endocarditis to observe the natural prognosis and influencing factors during the disease's progression and regression. Utilizing multi-omics technology, the study seeks to uncover the prognostic value of various biomarkers associated with the condition. The findings are expected to provide new insights into the pathogenesis, clinical diagnosis, and treatment strategies for infective endocarditis.
Why it matters
Potential benefit: If successful, this study could lead to improved early detection and targeted treatment options for patients with infective endocarditis.
How similar studies have gone: While the approach of using multi-omics technology in this context is relatively novel, similar studies have shown promise in understanding other infectious diseases.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with clinically confirmed infective endocarditis Exclusion Criteria: * Patients refuse to sign informed consent form * Patients who combined with serious systemic diseases, cannot tolerate the acquisition of biological samples
Where it's running
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First Affiliated Hospital of Xian Jiantong University
Xi'an, Shaanxi, China Recruiting
Study contacts
- Principal investigator: Yang Yan — First Affiliated Hospital Xi'an Jiaotong University
- Study coordinator: Guoliang Li
- Email: liguoliang_med@163.com
- Phone: +8613759982523
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Al[18F]F-NOTA-folate PET imaging in suspected cardiac sarcoidosis and infective endocarditis
This diagnostic test uses a folate-based PET tracer to see if it can help identify inflammation or infection in the heart for people with suspected cardiac sarcoidosis or infective endocarditis.
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Etiologic Diagnosis Algorithm in Infective Endocarditis
Aiming to see if a combined culture and molecular testing approach can help doctors choose the right antibiotics faster for adults with infective endocarditis.
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Rifampin-free therapy vs rifampin-containing therapy for staphylococcal prosthetic valve endocarditis
This study tests whether a rifampin-free antibiotic regimen can be as effective as a rifampin-containing regimen for adults with staphylococcal prosthetic valve endocarditis.
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Improving health and quality of life for patients recovering from infective endocarditis through cardiac rehabilitation
This study is testing if joining a cardiac rehabilitation program can help people recovering from infective endocarditis feel healthier and improve their quality of life.
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Echocardiography versus no echocardiography for Staphylococcus aureus bloodstream infection with VIRSTA score <3
This trial tests whether it is safe to skip routine echocardiography in adults hospitalized with Staphylococcus aureus bloodstream infection who have a VIRSTA score under 3.
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Barts Endocarditis Registry
This registry collects health, imaging, microbiology, treatment, and outcome information from adults with infective endocarditis seen at Barts Heart Centre to learn which approaches work best.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.