Condition

Immunodeficiency clinical trials and research

• 10Clinical trials
• 23NIH research projects
• 7Countries

Newest Immunodeficiency clinical trials

All recruiting trials (10)

• Optimizing antiviral treatment for immunocompromised people with COVID-19

  This trial will test whether adding remdesivir to Paxlovid or extending Paxlovid from 5 to 10 days helps immunocompromised people with asymptomatic or mild-to-moderate COVID-19.

  Recruiting at 4 sites Phase 2 University Hospital, Geneva · Basel, Basel and 3 other locations · NCT07406217

• Using CD45RA Depleted Stem Cells to Prevent Infections After Transplant

  This study is testing whether using special stem cells can help patients with high-risk leukemia recover their immune system faster and prevent infections after a stem cell transplant.

  Recruiting Phase 1/2 Children's Hospital of Philadelphia · Philadelphia, Pennsylvania · NCT06839456

• Investigating the effects of clozapine on immune function in Parkinson's disease

  This study tests how clozapine affects the immune system in people with Parkinson's disease who have psychotic symptoms, to see if it increases their risk of infections.

  Recruiting Phase 4 Centre Hospitalier Universitaire, Amiens · Salouël · NCT06634641

• Understanding vaccine responses in immunocompromised patients

  This study looks at how well vaccines work for people with weakened immune systems, like those with blood cancers or on certain treatments, to help improve their protection against respiratory viruses.

  Recruiting University of Cologne · Cologne, North Rhine-Westphalia · NCT06612515

• Analyzing immune system issues in patients

  This study is trying to collect blood and stool samples from people with immune system problems and healthy individuals to better understand these issues and help improve treatments.

  Recruiting Karolinska Institutet · Stockholm · NCT06248957

• Optimizing antiviral therapy for immunocompromised patients with COVID-19

  This study is testing if a combination of two antiviral medications can help immunocompromised patients with mild COVID-19 feel better and if taking one of the medications for longer makes a difference.

  Recruiting at 18 sites Phase 2 ANRS, Emerging Infectious Diseases · Bordeaux, Bordeaux and 17 other locations · NCT05587894

• Strategy using bacterial DNA detection to guide antibiotics in immunocompromised patients with ventilator-associated or hospital-acquired pneumonia

  This study tests whether using a PCR-based method to tailor antibiotics in immunocompromised ICU patients with suspected VAP or HAP on mechanical ventilation can improve the use of targeted antibiotics within 24 hours of diagnosis.

  Recruiting University Hospital, Lille · Lille · NCT05405491

• Allogeneic stem cell transplant for VEXAS Syndrome

  This study is testing if a stem cell transplant can help people with VEXAS Syndrome feel better and improve their health.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT05027945

• Stem cell transplant for GATA2 mutations

  This study is testing if a stem cell transplant can help people aged 8 to 70 with GATA2 mutations and related conditions feel better and produce healthy blood cells.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT01861106

• Genetic analysis of immune disorders

  This study is trying to find out which genes are linked to immune disorders to help patients and their families understand their health risks and how these conditions might be passed down.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00001467

NIH-funded research (23)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Sustained antibody delivery to durably control HIV-1

  A project aims to use gene-delivered antibodies to control HIV-1 for a long time without daily pills.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11424100

• Recognizing and Educating about Underdiagnosed Primary Immunodeficiency Disorders

  A patient-friendly look at a study aiming to find why primary immunodeficiency disorders are often missed and how to educate clinicians and patients to catch them earlier.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11417951

• Differential control of NK cell growth and survival in people with genetic replisome problems

  This grant looks at why natural killer (NK) cells—crucial for fighting infections and cancer—become defective when replisome genes are altered, with a focus on people who have related genetic conditions.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11378703

• Autologous, non-viral genome editing for ART-SCID (a patient-centered approach)

  A pediatric immunology researcher is developing a non-viral genome-editing therapy to repair Artemis-deficient SCID using a patient’s own blood-forming cells.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11332524

• EBV-related lymphoma in people with immune deficiency: understanding what drives the disease

  A doctor-scientist team will study a type of blood cancer linked to the Epstein-Barr virus in people with immune system problems to learn what makes it worse and how we can diagnose and treat it better.

  NIH research University of Vermont & St Agric College · Burlington, United States · NIH-11300775

• Lab-grown thymus cells to help T cell problems in CHARGE syndrome

  Researchers are growing thymus-supporting cells from stem cells to help people with CHARGE syndrome who have low T cell counts.

  NIH research University of Connecticut Storrs · Storrs-Mansfield, United States · NIH-11283956

• Abatacept for lung disease in people with common variable immunodeficiency (GLILD)

  This compares abatacept with a placebo to see whether abatacept can improve the lung disease (GLILD) that can occur in people with CVID.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11261089

• EBV-positive diffuse large B-cell lymphoma in people with weakened immune systems

  Researchers will compare tumor and virus features in people with EBV-positive diffuse large B-cell lymphoma who have weakened immune systems from HIV or medical treatments to better link biology to health outcomes.

  NIH research University of Vermont & St Agric College · Burlington, United States · NIH-11222776

• Understanding how EBV affects lymphoma in patients with weakened immune systems

  This study is looking at how the Epstein-Barr virus affects a type of cancer called diffuse large B-cell lymphoma, especially in people with weakened immune systems, like those with HIV, to help find better ways to diagnose and treat this illness.

  NIH research University of Vermont & St Agric College · Burlington, United States · NIH-11222775

• Improving gene therapy for treating RAG1 immunodeficiency

  This study is working on a new way to use gene editing with your own stem cells to help treat RAG1 immunodeficiency, a serious condition that affects your immune system, so that people without a matching donor can have a safer and more personalized treatment option.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11103261

• Understanding genetic causes of immune problems and infections in children

  This project aims to better understand the genetic changes that cause severe immune system problems and infections in children.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11096829

• Improving T cell function in older adults using a special protein treatment

  This study is looking at a new way to help older adults boost their immune system by using a special protein to improve the thymus, which is important for making T cells that fight off infections.

  NIH research University of Connecticut Storrs · Storrs-Mansfield, United States · NIH-11094822

• Evaluating cervical cancer screening methods for women with HIV in Botswana

  This study is looking at the best ways to screen for cervical cancer in women living with HIV in Botswana, and it invites 3,000 women to help find out which testing methods work best for keeping them healthy.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11093576

• Developing a new treatment for a specific immune deficiency using gene editing

  This study is exploring a new treatment for people with Artemis-deficient severe combined immunodeficiency (ART-SCID) by using a special gene-editing method to fix the genetic problem in their own blood stem cells, with the goal of helping their immune systems work better.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11033979

• Investigating a protein complex's role in immune system diseases and autoimmunity

  This study is looking at how changes in a specific gene might affect the immune system in children with immune disorders, to help us understand and find better treatments for those who struggle to fight infections.

  NIH research University of Washington · Seattle, United States · NIH-11019690

• Understanding and treating T cell issues in CHARGE syndrome using specialized cells

  This study is looking at how special cells made from stem cells can help people with CHARGE syndrome develop healthier immune systems by improving the function of their thymus, which is important for making T cells.

  NIH research University of Connecticut Storrs · Storrs-Mansfield, United States · NIH-11009900

• How stigma and social support affect cognitive function in older women with HIV

  This study is looking at how stigma related to HIV and gender affects the thinking skills of older women living with HIV/AIDS, and it also wants to see if having good social support can help protect their mental health.

  NIH research Yale University · New Haven, United States · NIH-11009236

• Understanding how mutations in a virus affect its behavior in animal models

  This study is looking at how changes in a specific virus protein affect how well the Human-Simian Immunodeficiency Virus (HSIV) can infect and grow in pigtail macaques, which helps researchers learn more about HIV and could lead to better treatments and vaccines for people living with HIV/AIDS.

  NIH research Texas Biomedical Research Institute · San Antonio, United States · NIH-10897301

• Using abatacept to treat lung disease in patients with common variable immunodeficiency.

  This study is looking at how well a medication called abatacept can help improve lung health in people with common variable immunodeficiency who have a specific lung condition, and it involves trying the drug for six months to see how it works.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-10893921

• Using CRISPR to fix genetic defects in the immune system

  This study is looking at how to fix genetic problems that cause primary immunodeficiency (PID), a condition that makes it hard for your immune system to work right, using a special technology called CRISPR to help create new treatments that could help people with PID feel better.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10884398

• Investigating a new model for HIV infection using pigtail macaques

  This study is creating a new way to study HIV using pigtail macaques, which will help researchers learn more about how the virus works and test new vaccines and treatments that could be more effective for people living with HIV.

  NIH research Texas Biomedical Research Institute · San Antonio, United States · NIH-10683253

• Identifying genetic defects that cause severe immune deficiencies in children

  This study is looking at the genetic causes of severe combined immune deficiencies (SCID) in kids, so doctors can better understand how to treat them with options like gene therapy or bone marrow transplants, helping to keep them healthy and safe from infections.

  NIH research Baylor College of Medicine · Houston, United States · NIH-10669125

• The relationship between oral bacteria and tooth decay in children with HIV

  This study looks at how the germs in the mouths of children with HIV might affect their risk of getting cavities, and it aims to find ways to help keep their teeth healthy.

  NIH research Clemson University · Clemson, United States · NIH-10424444

Related topics

Quick answers

How many Immunodeficiency clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (4 trials), France (3 trials), Switzerland (1 trial), Sweden (1 trial), Italy (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 1/2: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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