Sustained antibody delivery to durably control HIV-1

Who could benefit from this research

What this research studies

Researchers will test delivering protective antibodies via AAV vectors directly into muscle to sustain HIV-1 suppression. The approach builds on prior evidence that bnAbs can block infection and clear infected cells through Fc functions like ADCC and ADCP. The study will address key challenges such as anti-drug antibody responses, antibody escape, and reservoir depletion, with complementary work to understand what antibody features and delivery conditions work best. Findings could inform new, long-lasting HIV-1 control strategies beyond daily antiretroviral therapy.

Why it matters

Where this research is happening

• University of Wisconsin-Madison
  Madison, United States Active

Researchers

• Principal investigator: Evans, David T — University of Wisconsin-Madison
• Study coordinator: Evans, David T

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.