Evaluating cervical cancer screening methods for women with HIV in Botswana
Evaluation of triage strategies and screening intervals in a human papillomavirus based cervical cancer screening program in women living with human immunodeficiency virus in Botswana
['FUNDING_CAREER'] · BETH ISRAEL DEACONESS MEDICAL CENTER · NIH-11093576
This study is looking at the best ways to screen for cervical cancer in women living with HIV in Botswana, and it invites 3,000 women to help find out which testing methods work best for keeping them healthy.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BETH ISRAEL DEACONESS MEDICAL CENTER (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11093576 on ClinicalTrials.gov |
What this research studies
This research investigates the effectiveness of different cervical cancer screening methods using high-risk HPV testing specifically for women living with HIV in Botswana. It aims to establish a longitudinal cohort of 3,000 women, half of whom are HIV-positive, to assess the performance of various screening algorithms. Participants will undergo initial HPV testing followed by visual evaluations and biopsies to determine the best screening approach. The study seeks to provide evidence-based strategies for cervical cancer screening in high HIV prevalence settings.
Who could benefit from this research
Good fit: Ideal candidates for this research are women living with HIV in Botswana, particularly those aged 30 and older who are at risk for cervical cancer.
Not a fit: Patients who are not living with HIV or those who do not reside in Botswana may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cervical cancer screening protocols for women living with HIV, potentially reducing cancer incidence and mortality in this vulnerable population.
How similar studies have performed: Previous research has shown that HPV-based screening can be effective in high-income countries, but this approach is being tested for the first time in a high HIV prevalence setting like Botswana.
Where this research is happening
BOSTON, UNITED STATES
- BETH ISRAEL DEACONESS MEDICAL CENTER — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LUCKETT, REBECCA — BETH ISRAEL DEACONESS MEDICAL CENTER
- Study coordinator: LUCKETT, REBECCA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome, Acquired Immunodeficiency Syndrome Virus