Evaluating cervical cancer screening methods for women with HIV in Botswana
Official title: Evaluation of triage strategies and screening intervals in a human papillomavirus based cervical cancer screening program in women living with human immunodeficiency virus in Botswana
Funded at Beth Israel Deaconess Medical Center · NIH-11093576 · Data updated 2026-11-12
This study is looking at the best ways to screen for cervical cancer in women living with HIV in Botswana, and it invites 3,000 women to help find out which testing methods work best for keeping them healthy.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 1, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $255,961 |
| NIH project number | 5K08CA271949-04 |
| Project ID | NIH-11093576 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women living with HIV in Botswana, particularly those aged 30 and older who are at risk for cervical cancer.
✕Less likely to help
Patients who are not living with HIV or those who do not reside in Botswana may not benefit from this research.
What this research studies
This research investigates the effectiveness of different cervical cancer screening methods using high-risk HPV testing specifically for women living with HIV in Botswana. It aims to establish a longitudinal cohort of 3,000 women, half of whom are HIV-positive, to assess the performance of various screening algorithms. Participants will undergo initial HPV testing followed by visual evaluations and biopsies to determine the best screening approach. The study seeks to provide evidence-based strategies for cervical cancer screening in high HIV prevalence settings.
Why it matters
Potential benefit: If successful, this research could lead to improved cervical cancer screening protocols for women living with HIV, potentially reducing cancer incidence and mortality in this vulnerable population.
How similar studies have gone: Previous research has shown that HPV-based screening can be effective in high-income countries, but this approach is being tested for the first time in a high HIV prevalence setting like Botswana.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Luckett, Rebecca — Beth Israel Deaconess Medical Center
- Study coordinator: Luckett, Rebecca
Related research
Other NIH-funded projects on the same topics.
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mSaada: a mobile tool to boost cervical cancer screening in western Kenya
A mobile app helps community health volunteers manage cervical cancer screening tasks and follow-up for women in low-resource areas.
-
HPV self-collection in HIV care to screen for cervical cancer in Ethiopia
A patient-centered program tests a simple HPV self-collection approach within HIV clinics in Ethiopia to help detect cervical cancer earlier.
-
HOPE-inG: Increasing cervical cancer screening for women with HIV in Ghana
A study tests a home-based HPV self-sampling approach plus a tailored communication plan to help women living with HIV in Ghana get screened more often for cervical cancer.
-
CODA-based cervical cancer screening for LMICs using CRISPR and fluorescence
A low-resource, rapid test called CODA uses CRISPR and light signals to detect cervical cancer markers in women in sub-Saharan Africa to improve screening.
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CODA-based cervical cancer screening in low-resource settings
A new, quick, low-cost test using CRISPR and fluorescence readouts to help screen for cervical cancer in women in sub-Saharan Africa.
-
CATSystem: a digital tool to boost cervical cancer screening and follow-up in Kenya
A digital tracking system helps doctors and patients in Kenya improve cervical cancer screening, treatment referrals, and follow-up, especially for women living with HIV.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.