Investigating a protein complex's role in immune system diseases and autoimmunity
WAVE Regulatory Complex in Primary Immunodeficiency Disease and autoimmunity
This study is looking at how changes in a specific gene might affect the immune system in children with immune disorders, to help us understand and find better treatments for those who struggle to fight infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11019690 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the WAVE Regulatory Complex in primary immunodeficiency diseases and autoimmunity, particularly in children. It aims to explore how mutations in the NCKAP1L gene affect the immune system's ability to respond to infections and produce antibodies. By using advanced techniques like CRISPR/Cas9 and mouse models, the researchers will investigate the specific functions of Hematopoietic protein-1 in immune cell development and function. This could lead to better understanding and potential treatments for severe immune deficiencies.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who have been diagnosed with primary immunodeficiency diseases or exhibit symptoms of autoimmunity.
Not a fit: Patients with well-defined primary immunodeficiency diseases that are not linked to the WAVE Regulatory Complex may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for children with primary immunodeficiency diseases and autoimmune conditions.
How similar studies have performed: While the specific approach of targeting the WAVE Regulatory Complex is novel, similar research has shown promise in understanding immune deficiencies and developing targeted therapies.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Iritani, Brian M — University of Washington
- Study coordinator: Iritani, Brian M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.