Identifying genetic defects that cause severe immune deficiencies in children
Official title: Curation of genetic defects causing combined immunodeficiency and infections in children
Funded at Baylor College of Medicine · NIH-10669125 · Data updated 2026-11-12
This study is looking at the genetic causes of severe combined immune deficiencies (SCID) in kids, so doctors can better understand how to treat them with options like gene therapy or bone marrow transplants, helping to keep them healthy and safe from infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | July 1, 2021 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $344,400 |
| NIH project number | 5U24HD104590-03 |
| Project ID | NIH-10669125 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are newborns diagnosed with severe combined immune deficiencies or those identified through newborn screening programs.
✕Less likely to help
Patients with immune deficiencies not caused by genetic defects or those diagnosed after the newborn screening period may not benefit from this research.
What this research studies
This research focuses on understanding the genetic defects that lead to severe combined immune deficiencies (SCID) in children, which make them highly susceptible to infections. By analyzing genetic information from newborns identified through screening, the research aims to clarify the significance of various genetic variants. This will help healthcare providers make informed decisions about the most effective treatments, such as gene therapy or bone marrow transplants, ensuring timely and appropriate care for affected children.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and tailored treatments for children with severe immune deficiencies, improving their health outcomes.
How similar studies have gone: Previous research has shown success in identifying genetic causes of immune deficiencies, indicating that this approach has the potential for significant advancements.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Chinn, Ivan Kingyue — Baylor College of Medicine
- Study coordinator: Chinn, Ivan Kingyue
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.