Strategy using bacterial DNA detection to guide antibiotics in immunocompromised patients with ventilator-associated or hospital-acquired pneumonia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

RESPIRE is a randomized, unblinded study in ICU patients who are immunocompromised and require mechanical ventilation for suspected ventilator-associated or hospital-acquired pneumonia. It compares a PCR-based strategy to standard culture-based care to see if earlier, more precise antibiotic targeting can be achieved. The primary goal is to increase the proportion of patients receiving targeted antimicrobial therapy within 24 hours after diagnosis. Outcomes will consider antibiotic appropriateness and timing, with implications for antimicrobial stewardship in vulnerable populations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult immunocompromised patients hospitalized in ICU with suspected VAP or HAP requiring MV

Exclusion Criteria:

* No immunodeficiency Moribund patients (SAPS II \> 90) Pregnant women Refuse to participate to the study

Where it's running

• Houard
  Lille, France Recruiting

Study contacts

• Principal investigator: Marion HOUARD, MD — University Hospital, Lille
• Study coordinator: Marion HOUARD, MD
• Email: marion.houard@chru-lille.fr
• Phone: 0320445962

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.