Effects of a Single Workout on Gut Health in Women
The Acute Effects of an Endurance Exercise Bout the Gut Microbiome and Gut-derived Metabolome in Women's Distinct Fitness and Body Mass Indexes
This study is testing how a single workout affects gut health and metabolism in premenopausal women of different fitness levels and body types.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 21 Years to 40 Years |
| Sex | Female |
| Sponsor | George Washington University Academic / other |
| Locations | 1 site (Washington D.C., District of Columbia) |
| Trial ID | NCT06691100 on ClinicalTrials.gov |
What this trial studies
This study investigates how a single session of aerobic exercise impacts the gut microbiome and metabolic activity in premenopausal women with varying fitness levels and body types. Participants will undergo a series of assessments including body composition analysis, strength and endurance tests, and will provide stool and blood samples before and after a 30-minute exercise bout. The study aims to understand the relationship between exercise and gut health by measuring changes in specific bacteria and metabolites. The findings could provide insights into personalized exercise recommendations for weight management and overall health.
Who should consider this trial
Good fit: Ideal candidates are premenopausal women with a BMI between 19-24.99 or 30-40, who are either regular exercisers or sedentary.
Not a fit: Patients who are male, have a BMI outside the specified range, or have certain health conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to tailored exercise programs that improve gut health and aid in weight management for women.
How similar studies have performed: While studies on exercise and gut microbiome exist, this specific approach focusing on acute exercise effects in women with different fitness levels is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Biological sex: female * BMI 19 to 24.99 kg/m2 or BMI 30-40 kg/m2 * Exercisers: Exercise at least 4 times per week for 60 minutes (a total of 240 minutes per week) on a programmed exercise training either on endurance sports (e.g., running, cycling, triathlon), strength (e.g., powerlifting), or team sports (e.g., rugby, football, soccer) * Non-Exercisers: Sedentary individuals who have not reached the PA guidelines (150 minutes of moderate-intensity physical activity a week, 75 minutes of vigorous-intensity physical activity, or an equivalent combination of moderate and vigorous-intensity physical activity). Exclusion Criteria: * Biological sex: male * BMI \< 19 kg/m2 or \> 40 kg/m2 * Currently pregnant, \< 2 years postpartum, lactating * Currently taking any herbal, fiber, or prebiotic supplement * Current or 1-month before the study, taking oral or vaginal antibiotics * Diagnosed with any gastrointestinal, endocrine, digestive, cancer, or cardiovascular disease.
Where this trial is running
Washington D.C., District of Columbia
- Milken Institute School of Public Health, The George Washington University — Washington D.C., District of Columbia, United States (Recruiting)
Study contacts
- Study coordinator: Carmen Ortega-Santos, PhD, RD
- Email: carmen.ortegasantos@gwu.edu
- Phone: 2029942757
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.