Clinical trial Recruiting at 1 site Interventional Ages 40 to 75

Wild blueberry powder for joint and gut health

Official title: Effects of Dietary Wild Blueberries on Gut Health and Inflammation and Joint Pain

Run by University of Nevada, Las Vegas · NCT06828159 · Data updated 2026-11-12

This trial will test whether taking 25 g of freeze-dried wild blueberry powder daily for 12 weeks changes gut bacteria, lowers inflammation markers, and improves joint pain in adults with multi-joint or knee arthritis.

More Gut Microbiota trials

Quick facts

Study typeInterventional
Ages40 Years to 75 Years
SexAll
Enrollment50 (estimated)
SponsorUniversity of Nevada, Las Vegas
Academic / other
Drugs / interventionsprednisone
Locations1 site (Oklahoma City, Oklahoma)
StatusRecruiting
StartedSeptember 1, 2025
Main results expectedDecember 2027
Study endsMarch 2028
Registry record updatedNovember 5, 2025
Trial IDNCT06828159 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults with documented multi-joint or knee arthritis who are able to give informed consent, not pregnant or breastfeeding, not using recent berry extracts or high-dose corticosteroids, and without planned knee replacement or recent intra-articular injections are ideal candidates.

Probably not a fit

People with berry allergy, active cancer treatment, certain bone diseases, recent traumatic knee injury, or those on contraindicated medications may not benefit or may be excluded from participation.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with documented multi-joint or knee arthritis will consume 25 g of freeze-dried wild blueberry powder or a matched placebo powder for 12 weeks, with a 2-week washout period between treatment periods. The design uses two treatment periods so each participant receives both the blueberry and the placebo at different times. Outcomes include analysis of the gut microbiome, serum markers of inflammation, and measures of joint function and pain. Safety and adherence will be monitored throughout the intervention.

Why it matters

Potential benefit: If successful, this could offer a low-risk, dietary approach to improve gut microbiome profiles, reduce inflammation markers, and lessen joint pain symptoms.

How similar studies have gone: Some small clinical and preclinical studies suggest berries and anthocyanin-rich foods can modulate the gut microbiome and reduce inflammation, but strong clinical evidence for improving arthritis-related pain is limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Adults with documented multi-joint/knee arthritis

Exclusion Criteria:

* inability to give informed consent
* pregnancy or lactation
* planned knee replacement surgery
* allergy or contraindication to berries
* recent trauma of the knee responsible of the symptomatic knee
* intra-articular injection in the target knee/hip in the last 3 months
* oral corticosteroid therapy ≥ 5 mg/day (prednisone equivalent) at baseline
* use of berry extracts in the last 3 months
* special diets
* cancer treatment
* bone diseases

Where it's running

  • Omrf
    Oklahoma City, Oklahoma, United States
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.