Multispecies synbiotic in people on hemodialysis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-arm, open-label pilot trial evaluating the effect of multispecies synbiotic supplementation on the gut microbiome, gut permeability markers, and circulating uremic toxins in adults receiving maintenance hemodialysis for at least 3 months. Participants will take the synbiotic for 12 weeks, with assessments of fecal microbiota composition and serum levels of uremic toxins such as indoxyl sulfate. The study aims to see if modulating the gut ecosystem can decrease systemic toxin burden and improve intestinal barrier integrity. The results will inform feasibility, tolerability, and potential signals of benefit for larger controlled studies. The trial is conducted at a single center in Taichung, Taiwan, led by Tungs' Taichung Metroharbour Hospital.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18 years or older receiving maintenance hemodialysis patients for at least 3 months

Exclusion Criteria:

1. Use of probiotic supplements within the last month;
2. Hospitalization within the past month for acute infections or CKD-related complications;
3. History of major intestinal surgeries (gastrectomy, cholecystectomy; appendectomy allowed);
4. Presence of viral hepatitis, liver cirrhosis, active malignancy, advanced congestive heart failure, or thyroid disorders;
5. Use of antibiotics or immunosuppressive therapy within the preceding three months.

Where it's running

• Tungs' Taichung Metroharbour Hospital
  Taichung, Wuqi District, Taiwan Recruiting

Study contacts

• Study coordinator: Paik Seong Lim, PhD
• Email: jamespslim@gmail.com
• Phone: +886935045292

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.