Targeted NAD+ Replenishment to Protect Vein Grafts After Bypass
Official title: Targeted NAD+ Replenishment as Pre- and Post-bypass Therapy Against Vein Graft Failure
Funded at Northwestern University · NIH-11433243 · Data updated 2026-11-12
Aims to protect vein grafts used in bypass surgery by delivering NAD+ directly to vascular cells to reduce failure from aging and injury.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | August 15, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $812,196 |
| NIH project number | 1R01HL188253-01 |
| Project ID | NIH-11433243 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults undergoing or having undergone vein graft bypass who are at risk of graft failure may be eligible for future trials.
✕Less likely to help
Patients without vein grafts or those not at risk of graft failure are unlikely to benefit.
What this research studies
After bypass surgery, vein grafts often fail due to endothelial damage and vessel remodeling. This project tests a nanoparticle therapy that delivers NAD+ into vein graft cells to maintain energy and balance during pre- and post-surgery periods. It uses a biomimetic, platelet-coated NAD+-loaded nanoparticle to reach grafts specifically and support endothelial health. The approach shows promise in preserving graft function in models and early studies, with a focus on translating to patients who need bypass procedures.
Why it matters
Potential benefit: If successful, patients could experience lower vein graft failure rates and longer-lasting grafts after bypass surgery.
How similar studies have gone: Preclinical data indicate NAD+ delivery can preserve endothelial health and improve graft patency in models, supporting further development.
Where this research is happening
-
Northwestern University
Chicago, United States Active
Researchers
- Principal investigator: Wang, Bowen — Northwestern University
- Study coordinator: Wang, Bowen
Related research
Other NIH-funded projects on the same topics.
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Gene therapies to prevent vein graft failure in heart and leg surgeries
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Gene therapies to prevent failure of prosthetic bypass grafts
This study is looking at a new way to help people with severe leg artery blockages by using a special treatment to improve the success of prosthetic grafts, which can sometimes fail and lead to serious problems like losing a limb.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.