Gene therapies to prevent failure of prosthetic bypass grafts
Official title: Targeted Gene Therapies for the Prevention of Prosthetic Bypass Graft Failure
Funded at Beth Israel Deaconess Medical Center · NIH-11028761 · Data updated 2026-11-12
This study is looking at a new way to help people with severe leg artery blockages by using a special treatment to improve the success of prosthetic grafts, which can sometimes fail and lead to serious problems like losing a limb.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | December 26, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $786,188 |
| NIH project number | 1R01HL177355-01 |
| Project ID | NIH-11028761 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with critical blockages in their leg arteries who may require prosthetic bypass grafts.
✕Less likely to help
Patients who do not require bypass grafts or have adequate quality saphenous veins for grafting may not benefit from this research.
What this research studies
This research focuses on improving the success rates of prosthetic bypass grafts used in patients with severe arterial blockages in the legs. It aims to address the high failure rates of these grafts, which can lead to serious complications like limb loss. The approach involves using small interfering RNA (siRNA) therapy to target and reduce the expression of specific genes that contribute to graft failure. By doing so, the research hopes to enhance the healing process at the connection points of the grafts and arteries, ultimately improving patient outcomes.
Why it matters
Potential benefit: If successful, this research could significantly reduce the risk of failure for patients undergoing prosthetic bypass graft procedures.
How similar studies have gone: Previous research has shown promise in using siRNA therapies to mitigate vascular complications, indicating potential for success in this approach.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Liang, Patric — Beth Israel Deaconess Medical Center
- Study coordinator: Liang, Patric
Related research
Other NIH-funded projects on the same topics.
-
Targeted NAD+ Replenishment to Protect Vein Grafts After Bypass
Aims to protect vein grafts used in bypass surgery by delivering NAD+ directly to vascular cells to reduce failure from aging and injury.
-
Gene therapy to protect vein grafts after bypass surgery
Testing a gene therapy meant to help veins used in bypass operations stay open longer for people with coronary or peripheral artery disease.
-
Targeted gene therapy to protect prosthetic leg bypass grafts
This project uses targeted gene-silencing treatments to prevent narrowing and failure of synthetic bypass grafts in people with blocked leg arteries.
-
Improving vein graft success after heart bypass surgery
This project uses computer models to design better ways to prevent vein grafts from failing after coronary artery bypass surgery.
-
Gene therapies to prevent vein graft failure in heart and leg surgeries
This study is looking at a new way to help improve the success of vein grafts used in heart and leg surgeries, especially for people with coronary artery disease and peripheral arterial disease, by using a special gene therapy that could help keep the grafts healthy and working better for longer.
-
Understanding why transplanted hearts fail over time
This study is looking at how heart transplants can sometimes fail over time, especially when the heart muscle gets too thick, and it aims to understand the different types of cells involved in this process to help improve the health and longevity of transplanted hearts for patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.