Gene therapies to prevent failure of prosthetic bypass grafts
Targeted Gene Therapies for the Prevention of Prosthetic Bypass Graft Failure
This study is looking at a new way to help people with severe leg artery blockages by using a special treatment to improve the success of prosthetic grafts, which can sometimes fail and lead to serious problems like losing a limb.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11028761 on NIH RePORTER |
What this research studies
This research focuses on improving the success rates of prosthetic bypass grafts used in patients with severe arterial blockages in the legs. It aims to address the high failure rates of these grafts, which can lead to serious complications like limb loss. The approach involves using small interfering RNA (siRNA) therapy to target and reduce the expression of specific genes that contribute to graft failure. By doing so, the research hopes to enhance the healing process at the connection points of the grafts and arteries, ultimately improving patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with critical blockages in their leg arteries who may require prosthetic bypass grafts.
Not a fit: Patients who do not require bypass grafts or have adequate quality saphenous veins for grafting may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the risk of failure for patients undergoing prosthetic bypass graft procedures.
How similar studies have performed: Previous research has shown promise in using siRNA therapies to mitigate vascular complications, indicating potential for success in this approach.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Liang, Patric — Beth Israel Deaconess Medical Center
- Study coordinator: Liang, Patric
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.