Using a 3D printed device to prevent vein graft failure after heart surgery
Preclinical testing of a 3D printed external scaffold device to prevent vein graft failure after coronary bypass graft surgery
['FUNDING_OTHER'] · BIOGRAFT, INC. · NIH-10385132
This study is testing a new biodegradable device that helps keep vein grafts working well after heart surgery, aiming to help many patients avoid complications and improve their recovery.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BIOGRAFT, INC. (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-10385132 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a biodegradable external scaffold device designed to prevent the failure of saphenous vein grafts used in coronary artery bypass grafting (CABG). The project aims to address the significant issue of vein graft failure, which affects a large number of patients undergoing CABG surgery. By gradually increasing mechanical loading on the grafts, the researchers hope to improve graft adaptation and reduce the risk of occlusion. The study builds on previous successful findings in animal models and seeks to create a scalable manufacturing process for the device.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients scheduled for coronary artery bypass grafting who may benefit from improved graft longevity.
Not a fit: Patients who are not undergoing CABG surgery or those with alternative treatment plans for coronary artery disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the rate of vein graft failure, improving outcomes for patients undergoing coronary artery bypass surgery.
How similar studies have performed: Previous research has shown promising results in animal models using similar approaches to prevent graft failure, indicating potential for success in human applications.
Where this research is happening
STANFORD, UNITED STATES
- BIOGRAFT, INC. — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WILSON, NATHAN MARSHALL — BIOGRAFT, INC.
- Study coordinator: WILSON, NATHAN MARSHALL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Coronary Artery Disease, Coronary Artery Disorder