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Clinical trial Recruiting at 1 site Observational Ages 18 to 90

Evaluating heart patients with previous bypass surgery for graft issues and heart disease progression

Official title: Patients With Prior Coronary Artery Bypass Graft Surgery Evaluated for Saphenous VeIn grAft DysfUnction and Progression of Coronary arTery Disease

Run by Amsterdam UMC, location VUmc · NCT04772768 · Data updated 2026-11-12

This study is trying to see how heart patients who had bypass surgery and are having chest pain again are doing over time, especially looking at issues with their grafts and heart disease.

Quick facts

Study typeObservational
Ages18 Years to 90 Years
SexAll
Enrollment500 (estimated)
SponsorAmsterdam UMC, location VUmc
Academic / other
Locations1 site (Amsterdam)
StatusRecruiting
StartedAugust 23, 2019
Main results expectedJuly 23, 2024
Study endsJuly 23, 2029
Registry record updatedJune 2, 2023
Trial IDNCT04772768 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include patients aged 18 to 90 with a history of CABG and recurrent angina symptoms.

Probably not a fit

Patients under 18, over 90, in cardiogenic shock, pregnant, or unable to provide informed consent may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational cohort study focuses on patients who have undergone coronary artery bypass grafting (CABG) and are experiencing recurrent ischemic symptoms. It aims to investigate the clinical outcomes of these patients, particularly looking at bypass graft failure and the progression of native coronary artery disease. Data will be collected through national registry databases, electronic medical records, and standardized telephonic assessments at 3 and 5 years follow-up. The study addresses the challenges in managing patients with recurrent angina after CABG, who often have complex medical histories and comorbidities.

Why it matters

Potential benefit: If successful, this study could improve the understanding and management of recurrent angina in patients with prior CABG, leading to better clinical outcomes.

How similar studies have gone: While there have been studies on CABG outcomes, this specific observational approach focusing on recurrent angina and graft dysfunction in this patient population is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Prior coronary artery bypass grafting
* One or more saphenous vein grafts
* Recurrent angina symptoms

Exclusion Criteria:

* \<18 years of age
* ≥ 90 years of age
* Cardiogenic shock
* Pregnancy
* Failure to provide informed consent

Where it's running

  • Amsterdam University Medical Centers, Department of Cardiology
    Amsterdam, Netherlands     Recruiting

Study contacts

  • Principal investigator: Paul Knaapen, Professor — Amsterdam University Medical Centers, Department of Cardiology
  • Study coordinator: Paul Knaapen, Professor
  • Email: p.knaapen@amsterdamumc.nl
  • Phone: +31 20 444 0123

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.