Evaluating heart patients with previous bypass surgery for graft issues and heart disease progression
Patients With Prior Coronary Artery Bypass Graft Surgery Evaluated for Saphenous VeIn grAft DysfUnction and Progression of Coronary arTery Disease
This study is trying to see how heart patients who had bypass surgery and are having chest pain again are doing over time, especially looking at issues with their grafts and heart disease.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 18 Years to 90 Years |
| Sex | All |
| Sponsor | Amsterdam UMC, location VUmc Academic / other |
| Locations | 1 site (Amsterdam) |
| Trial ID | NCT04772768 on ClinicalTrials.gov |
What this trial studies
This observational cohort study focuses on patients who have undergone coronary artery bypass grafting (CABG) and are experiencing recurrent ischemic symptoms. It aims to investigate the clinical outcomes of these patients, particularly looking at bypass graft failure and the progression of native coronary artery disease. Data will be collected through national registry databases, electronic medical records, and standardized telephonic assessments at 3 and 5 years follow-up. The study addresses the challenges in managing patients with recurrent angina after CABG, who often have complex medical histories and comorbidities.
Who should consider this trial
Good fit: Ideal candidates include patients aged 18 to 90 with a history of CABG and recurrent angina symptoms.
Not a fit: Patients under 18, over 90, in cardiogenic shock, pregnant, or unable to provide informed consent may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the understanding and management of recurrent angina in patients with prior CABG, leading to better clinical outcomes.
How similar studies have performed: While there have been studies on CABG outcomes, this specific observational approach focusing on recurrent angina and graft dysfunction in this patient population is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Prior coronary artery bypass grafting * One or more saphenous vein grafts * Recurrent angina symptoms Exclusion Criteria: * \<18 years of age * ≥ 90 years of age * Cardiogenic shock * Pregnancy * Failure to provide informed consent
Where this trial is running
Amsterdam
- Amsterdam University Medical Centers, Department of Cardiology — Amsterdam, Netherlands (Recruiting)
Study contacts
- Principal investigator: Paul Knaapen, Professor — Amsterdam University Medical Centers, Department of Cardiology
- Study coordinator: Paul Knaapen, Professor
- Email: p.knaapen@amsterdamumc.nl
- Phone: +31 20 444 0123
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.