Investigating graft failure after heart bypass surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational cohort study aims to understand the causes of graft failure following coronary artery bypass graft (CABG) surgery. It will utilize total-body Positron Emission Tomography (PET) scans to examine inflammation, thrombosis, and fibrosis in saphenous vein grafts. Participants will be divided into two cohorts: one undergoing CABG surgery and another with suspected vein graft failure. Clinical reviews, blood sampling, echocardiograms, and advanced imaging techniques will be employed to gather comprehensive data over time.

Why it matters

Who can join: the full rules

INCLUSION CRITERIA:

Cohort 1: Patients undergoing CABG surgery

* Males and females over 18 years of age
* Patients undergoing CABG surgery for multivessel coronary artery disease, who receive at least one saphenous vein graft

Cohort 2: Patients with symptomatic saphenous vein graft vasculopathy

* Males and females over 18 years of age
* Patients who underwent CABG surgery ≥ 5 years prior to recruitment for multivessel disease and received 2 or more saphenous vein grafts
* Referred for invasive coronary angiography due to recurrent symptoms and with a high suspicion of graft vasculopathy

EXCLUSION CRITERIA:

* Patients with a life expectancy of \< 2 years
* Renal failure (estimated glomerular filtration rate \<30 mL/min/1.73 m2)
* Patients on immunosuppressive therapies
* Females of child-bearing age who are pregnant or breastfeeding,
* Known allergy or contraindications to iodinated contrast or radiotracer
* Patients who are unable to tolerate the supine position
* Patients who are unable to provide informed consent

Where it's running

• Royal Infirmary of Edinburgh
  Edinburgh, Midlothian, United Kingdom Recruiting

Study contacts

• Study coordinator: Laura E Clark, BSc, MBChB, MRCS(Ed)
• Email: lclark15@ed.ac.uk
• Phone: +447717478087

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.