Modified second transplantation for patients with graft failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates a modified regimen for second allogeneic stem cell transplantation in patients who have experienced graft failure after their first transplant. The aim is to enhance hematopoietic reconstitution and improve recovery outcomes, particularly focusing on patients who have not fully recovered their platelet counts. It is a prospective, single-arm study that evaluates the safety and efficacy of this new approach. The study includes patients with hematological malignancies who meet specific eligibility criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 1.Primary disease: hematological malignancies(AML, CML, MDS, lymphoma, etc.); 2.Graft failure after first allogeneic stem cell transplantation; 3.Time from the first transplantation to the second transplantation is less than 180 days; 4. Age≥14 years.

Exclusion Criteria:

* 1\. Active infections; 2. Active GVHD; 3. Organ dysfunction: hepatic injury (Tbil≥2ULN), renal injury (Cr≥1.5ULN), heart injury (EF%\<50% or symptomatic heart failure); 4. Eastern Cooperative Oncology Group (ECOG) score\>2; 5. Expected life time\<30 days; 5. Patients could not cooperate; 6. Other situations that are considered inappropriate for enrollment by the investigators,

Where it's running

• Peking University People's Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Principal investigator: Xiao-Jun Huang, M.D. — Institute of Hematology, Peking University People's Hospital
• Study coordinator: Yu-qian Sun, M.D.
• Email: sunyuqian83@hotmail.com
• Phone: +86-10-88324577

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Ruxolitinib-enhanced haploidentical transplant for children and young adults with sickle cell disease

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.