Understanding early signs of dementia with Lewy bodies
Official title: Deep Phenotypic Characterization of Prodromal Dementia with Lewy Bodies
Funded at University of Miami School of Medicine · NIH-10670501 · Data updated 2026-11-12
This study is looking at the early signs of dementia with Lewy bodies to help doctors spot it more easily and quickly, so if you or someone you know is experiencing these symptoms, this research could lead to better ways to diagnose and treat this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | September 30, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $3,171,435 |
| NIH project number | 1R56AG074889-01A1 |
| Project ID | NIH-10670501 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing early cognitive decline, motor changes, or behavioral symptoms that may indicate dementia with Lewy bodies.
✕Less likely to help
Patients with other forms of dementia or those who do not exhibit symptoms related to Lewy body dementia may not benefit from this research.
What this research studies
This research investigates the early symptoms and characteristics of dementia with Lewy bodies (DLB), which affects cognitive function and motor skills. It aims to improve the diagnosis of DLB by developing standardized assessment tools that can better identify the condition and its prodromal stages. By focusing on the unique symptoms of DLB, the research seeks to differentiate it from other types of dementia, such as Alzheimer's disease. Patients will be evaluated using new diagnostic criteria to enhance early detection and treatment options.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnoses of dementia with Lewy bodies, improving treatment outcomes for patients.
How similar studies have gone: Previous research has shown success in improving diagnostic criteria for other types of dementia, suggesting that this approach may also yield valuable insights for DLB.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Galvin, James E — University of Miami School of Medicine
- Study coordinator: Galvin, James E
Related research
Other NIH-funded projects on the same topics.
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Understanding how heparan sulfate affects alpha-synuclein in Lewy body dementia
A small study in people who have dementia with Lewy bodies looks at how a brain sugar (heparan sulfate) helps a harmful protein (alpha-synuclein) spread, with the hope of slowing disease progression.
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Alpha-synuclein seed test in blood or urine for Parkinson’s and Lewy body diseases
A new blood or urine test using seed amplification to help diagnose Parkinson’s disease, dementia with Lewy bodies, and related conditions earlier and more clearly.
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Dementia with Lewy Bodies Consortium
A national research effort to better understand and diagnose Lewy body dementia by studying biomarkers and patient data over time.
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Rat model of dementia with Lewy bodies may help us study memory and movement problems
A scientist team is creating and validating a rat model that mirrors Dementia with Lewy Bodies to better understand how it develops and to test potential treatments.
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Proof of Concept Study on Clinical Trial Outcomes and Biomarkers in Early Lewy Body Dementia
A small, early-stage study is testing whether new biomarkers and trial outcomes can better measure symptoms and treatment effects for people with Lewy body dementia.
-
Amyloid-clearing therapy for dementia with Lewy bodies plus Alzheimer's disease
A study tests an amyloid-clearing antibody in people who have both Dementia with Lewy bodies and Alzheimer's disease to see if it can safely help with their symptoms.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.