Investigating heart fat accumulation in women with coronary microvascular dysfunction and its link to heart failure.
Official title: Myocardial Steatosis in Women with Coronary Microvascular Dysfunction: Defining the Pathway to Heart Failure with Preserved Ejection Fraction (HFpEF)
Funded at Cedars-Sinai Medical Center · NIH-10897016 · Data updated 2026-11-12
This study is looking at how problems with small blood vessels in the heart can affect women and lead to heart failure, and it aims to find new ways to help improve heart health for those who are impacted.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | July 1, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $617,876 |
| NIH project number | 5R01HL153500-04 |
| Project ID | NIH-10897016 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women diagnosed with coronary microvascular dysfunction who are at risk of developing heart failure.
✕Less likely to help
Patients who do not have coronary microvascular dysfunction or heart failure may not benefit from this research.
What this research studies
This research focuses on understanding how coronary microvascular dysfunction (CMD) affects women and contributes to heart failure with preserved ejection fraction (HFpEF). It examines the metabolic changes in heart cells due to CMD, particularly the accumulation of fat in the heart muscle, which may lead to heart failure. By studying these processes, the research aims to identify potential pathways for targeted therapies that could improve heart health in affected women. Patients may undergo various assessments to evaluate heart function and metabolic changes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments specifically designed for women suffering from heart failure with preserved ejection fraction.
How similar studies have gone: Previous research has indicated that understanding metabolic changes in heart conditions can lead to significant advancements in treatment, suggesting potential success for this approach.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Wei, Janet — Cedars-Sinai Medical Center
- Study coordinator: Wei, Janet
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.