Understanding Heart Fat Accumulation in Women with Small Heart Vessel Problems and Heart Failure

Who could benefit from this research

What this research studies

Heart failure with preserved ejection fraction (HFpEF) is a serious condition, and women are more likely to develop it, yet there are no specific treatments. We know that problems with the heart's small blood vessels, called coronary microvascular dysfunction (CMD), are common in women and often lead to HFpEF. Our work suggests that when these small vessels don't work well, it can cause fat to build up in the heart muscle, which might be a key step towards developing HFpEF. This research will explore this connection to better understand why HFpEF develops in women with CMD.

Why it matters

Where this research is happening

• Cedars-Sinai Medical Center
  Los Angeles, United States Active

Researchers

• Principal investigator: Wei, Janet — Cedars-Sinai Medical Center
• Study coordinator: Wei, Janet

Related research

Other NIH-funded projects on the same topics.

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  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-10897016

• Understanding how coronary microvascular dysfunction can lead to heart failure in women.

  This study is looking into how problems with small blood vessels in the heart can lead to heart failure, especially in women, and it aims to find better treatments for those at risk due to factors like high blood pressure, obesity, and changes in estrogen levels.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-10576287

• AI-supported heart failure diagnosis and management in Rwanda

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  NIH research Boston Medical Center · Boston, United States · NIH-11625877

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  NIH research Boston Medical Center · Boston, United States · NIH-11625876

• HF endotypes in heart failure using ethical multi-modal AI and molecular data

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• Triple gene therapy approach to heal the heart after a heart attack

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  NIH research Baylor College of Medicine · Houston, United States · NIH-11621120

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.