Understanding how heart conditions affect tolerance to rapid heart rates
Coronary Epicardial and Microcirculatory Determinants of Ventricular Tachycardia Tolerability
This study is testing how well people with heart conditions, especially those with coronary artery disease, can handle fast heart rates and whether treating their condition with stents can help them tolerate it better.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 70 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Imperial College London Academic / other |
| Locations | 1 site (London) |
| Trial ID | NCT05841199 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the factors that influence how well patients tolerate ventricular tachycardia (VT), particularly focusing on the impact of coronary artery disease. Participants undergoing coronary angiograms or angioplasty will have their blood pressure, coronary pressure, and flow measured during induced rapid heart rates. The study seeks to determine whether treating coronary artery disease with stents can improve VT tolerability. By identifying these factors, the research could help tailor patient management and potentially reduce the need for implantable cardioverter defibrillators (ICDs).
Who should consider this trial
Good fit: Ideal candidates are patients referred for coronary angiography or angioplasty who can provide valid consent.
Not a fit: Patients with unstable coronary artery disease, severe heart valve disease, or severe heart failure may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for patients with ventricular tachycardia, potentially reducing reliance on ICDs.
How similar studies have performed: While this approach is observational and may build on existing knowledge, it addresses a specific gap in understanding VT tolerability, making it a novel investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Able to give valid consent * Referred for coronary angiography or coronary angioplasty * Suitable for percutaneous physiological interrogation and PCI when clinically indicated Exclusion Criteria: * Unable to give valid consent * Pregnant or breastfeeding women * Unstable coronary artery disease (acute coronary syndrome) * Severe multivessel coronary artery disease suitable for coronary artery bypass grafting * Severe heart valve disease * Severe (NYHA IV) heart failure
Where this trial is running
London
- Imperial College NHS Foundation Trust — London, United Kingdom (Recruiting)
Study contacts
- Principal investigator: Ricardo Petraco — Senior Clinical Research Fellow
- Study coordinator: Rahul Bahl
- Email: r.bahl@imperial.ac.uk
- Phone: +44 20 7594 1093
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.