Understanding how heart conditions affect tolerance to rapid heart rates

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the factors that influence how well patients tolerate ventricular tachycardia (VT), particularly focusing on the impact of coronary artery disease. Participants undergoing coronary angiograms or angioplasty will have their blood pressure, coronary pressure, and flow measured during induced rapid heart rates. The study seeks to determine whether treating coronary artery disease with stents can improve VT tolerability. By identifying these factors, the research could help tailor patient management and potentially reduce the need for implantable cardioverter defibrillators (ICDs).

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Able to give valid consent
* Referred for coronary angiography or coronary angioplasty
* Suitable for percutaneous physiological interrogation and PCI when clinically indicated

Exclusion Criteria:

* Unable to give valid consent
* Pregnant or breastfeeding women
* Unstable coronary artery disease (acute coronary syndrome)
* Severe multivessel coronary artery disease suitable for coronary artery bypass grafting
* Severe heart valve disease
* Severe (NYHA IV) heart failure

Where it's running

• Imperial College NHS Foundation Trust
  London, United Kingdom Recruiting

Study contacts

• Principal investigator: Ricardo Petraco — Senior Clinical Research Fellow
• Study coordinator: Rahul Bahl
• Email: r.bahl@imperial.ac.uk
• Phone: +44 20 7594 1093

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.