Magnesium status in people with IBD, ileostomy, or bile acid diarrhea
Magnesium Status in Patients With Gastrointestinal Disease
This will test different ways to check magnesium in adults with Crohn's disease, ulcerative colitis, ileostomies, or bile acid diarrhea to see which method best finds deficiency.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 120 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Aarhus Academic / other |
| Locations | 1 site (Aarhus N) |
| Trial ID | NCT07338565 on ClinicalTrials.gov |
What this trial studies
This cross-sectional study enrolls adults with inflammatory bowel disease, ileostomy, or bile acid diarrhoea and a group of healthy controls to compare multiple biochemical and functional magnesium markers. Participants will attend up to four visits during which blood, cellular, and possibly urine tests and functional assessments will be performed to compare plasma magnesium with intracellular and other measures. The aim is to identify which tests most accurately and practically reflect whole-body magnesium status in people with chronic intestinal disorders. Results are intended to inform a more sensitive screening approach for magnesium deficiency in clinical practice.
Who should consider this trial
Good fit: Adults aged 18 or older who understand Danish and have a diagnosis of Crohn's disease, ulcerative colitis, an ileostomy, or bile acid diarrhoea (or healthy volunteers for the control group) are the intended participants.
Not a fit: People who are pregnant or breastfeeding, under 18, unable to understand Danish, or who have used oral magnesium supplements recently are not eligible and are unlikely to gain direct benefit from participation.
Why it matters
Potential benefit: If successful, the work could lead to earlier and more accurate detection of magnesium deficiency, enabling targeted treatment and improved symptoms and quality of life for affected patients.
How similar studies have performed: Prior work has shown routine plasma magnesium often misses deficiency and smaller studies suggest intracellular or functional tests can be more sensitive, but comprehensive comparisons specifically in gastrointestinal patient groups remain limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: \- Age 18 or older, mentally competent, and able to understand Danish. Group 1: \- Diagnosed with IBD (DK50X, Crohn's disease, or DK51X, ulcerative colitis), ileostomy (DZ932) or bile acid diarrhoea (DSK908B) (Se-HCAT scintigraphy showing residual activity \<10%). Group 2: \- Healthy individuals. Exclusion Criteria: * Pregnant or breastfeeding. * Use of oral magnesium supplements for more than 2 weeks before inclusion.
Where this trial is running
Aarhus N
- Department of Hepatology and Gastroenterology, Aarhus University Hospital — Aarhus N, Denmark (Recruiting)
Study contacts
- Study coordinator: Mathias Redsted
- Email: matred@clin.au.dk
- Phone: +4530519619
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.