Investigating how a high-fat/high-protein diet affects Clostridioides difficile infections
A systems-level approach to probe the effect of a high- fat/high-protein diet in Clostridioides difficile infection
['FUNDING_R15'] · UNIVERSITY OF NEVADA LAS VEGAS · NIH-10515273
This study is looking at how a high-fat and high-protein diet affects people with Clostridioides difficile infections, which can happen after taking antibiotics, to see if changing what you eat could help improve your gut health and fight the infection.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NEVADA LAS VEGAS (nih funded) |
| Locations | 1 site (LAS VEGAS, UNITED STATES) |
| Trial ID | NIH-10515273 on ClinicalTrials.gov |
What this research studies
This research explores the impact of a high-fat/high-protein diet on Clostridioides difficile infection (CDI), a significant cause of healthcare-associated infections. Using a mouse model, the study examines how this diet influences the gut microbiome and the body's response to CDI, particularly in the context of antibiotic use. The researchers aim to understand the mechanisms by which diet may exacerbate or mitigate the severity of CDI, potentially leading to new dietary recommendations for at-risk patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for CDI, particularly those who have recently used antibiotics or have a history of gastrointestinal issues.
Not a fit: Patients who do not have a history of CDI or are not at risk for gastrointestinal infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to dietary guidelines that help prevent or reduce the severity of Clostridioides difficile infections in patients.
How similar studies have performed: While there have been studies on diet and gut health, this specific approach to understanding the interaction between diet and CDI is relatively novel and has not been extensively tested.
Where this research is happening
LAS VEGAS, UNITED STATES
- UNIVERSITY OF NEVADA LAS VEGAS — LAS VEGAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HEDLUND, BRIAN P — UNIVERSITY OF NEVADA LAS VEGAS
- Study coordinator: HEDLUND, BRIAN P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: disease carrier state