How antibiotics versus fecal transplants affect recovery from C. difficile infection

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project follows adults with microbiologically confirmed C. difficile infection who receive routine care with either standard antibiotics or fecal microbiota transplantation (FMT). Treatment decisions are made by the treating physician and the research team collects stool and other biological samples during the acute episode and at predefined follow‑up visits for up to five years. Samples will be analyzed for microbiota composition, microbial metabolites, intestinal barrier markers, and mucosal and systemic immune responses and these measures will be related to clinical outcomes and patient‑reported quality of life. The study aims to identify microbial and metabolic signatures linked to recovery or treatment failure and to characterize short‑ and long‑term effects of each therapy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18 years or older
* Symptomatic, microbiologically verified Clostridioides difficile infection
* Receiving inpatient or outpatient care at Umeå University Hospital
* Able and willing to provide written informed consent
* Willing to participate in protocol-driven follow-up for up to 5 years

Exclusion Criteria:

* Age below 18 years
* Inability to provide written informed consent

Where it's running

• Umeå University Hospital
  Umeå, Sweden Recruiting

Study contacts

• Principal investigator: Johan Rasmuson, MD, PhD — Umeå University, Department of Clinical Microbiology and Umeå University Hospital, Department of Infectious Diseases
• Study coordinator: Johan Rasmuson, MD, PhD
• Email: johan.rasmuson@umu.se
• Phone: 0046-907850000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.