Investigating how gut bacteria interact with Clostridioides difficile infections
High-resolution genomic interrogation of pathogen-microbiome interactions in Clostridioides difficile infection
This study is looking at how a harmful germ called Clostridioides difficile interacts with the good bacteria in the gut of people who have infections, to help find out why some people get sicker than others and to improve treatments for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11093474 on NIH RePORTER |
What this research studies
This research focuses on understanding the interactions between Clostridioides difficile, a harmful bacterium, and the gut microbiome in patients suffering from infections. By analyzing stool samples from over 30,000 patients, the study aims to uncover the genetic factors that influence the severity of these infections and the role of the gut microbiome in either exacerbating or mitigating the disease. The approach involves high-resolution genomic analysis to identify specific genetic elements associated with different outcomes of Clostridioides difficile infections. This could lead to better-targeted treatments and improved patient care.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have been diagnosed with Clostridioides difficile infections or are at risk of developing them.
Not a fit: Patients who do not have Clostridioides difficile infections or related gastrointestinal issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for Clostridioides difficile infections, reducing recurrence rates and improving patient outcomes.
How similar studies have performed: Previous research has shown promise in understanding pathogen-microbiome interactions, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Dantas, Gautam — Washington University
- Study coordinator: Dantas, Gautam
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.