Exploring immune responses to fight Clostridioides difficile infections
Understanding and leveraging immunometabolism to combat Clostridioides difficile infection
['FUNDING_R01'] · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · NIH-10897165
This study is looking at how certain immune cells in your body can be activated to help fight off Clostridioides difficile infections, with the goal of finding new ways to boost your immune response and improve treatments for this infection.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR (nih funded) |
| Locations | 1 site (OKLAHOMA CITY, UNITED STATES) |
| Trial ID | NIH-10897165 on ClinicalTrials.gov |
What this research studies
This research aims to understand how specific immune cells, known as group 3 innate lymphocytes (ILC3s), can be activated to improve the body's defense against Clostridioides difficile infections (CDI). The study focuses on the interaction between these immune cells and the bacteria, particularly how a toxin produced by C. difficile can stimulate ILC3s to release protective substances. By investigating the metabolic pathways that influence ILC3 activation, the researchers hope to identify new strategies to enhance immune responses and potentially develop better treatments for CDI.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced or are at risk for Clostridioides difficile infections.
Not a fit: Patients who do not have a history of Clostridioides difficile infections or related gastrointestinal issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for patients suffering from Clostridioides difficile infections.
How similar studies have performed: Previous studies have shown promise in enhancing immune responses through similar approaches, indicating potential for success in this research.
Where this research is happening
OKLAHOMA CITY, UNITED STATES
- UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR — OKLAHOMA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZENEWICZ, LAUREN A — UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
- Study coordinator: ZENEWICZ, LAUREN A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bacterial Infections