NIH-funded research NIH-funded research

How pet ownership affects gut health and Clostridioides difficile infections

Official title: Impact of pet contact on antimicrobial-associated dysbiosis and Clostridioides difficile infection

Funded at University of Pennsylvania · NIH-11044056 · Data updated 2026-11-12

This study is looking at how having pets might help your gut health bounce back after taking antibiotics, especially when it comes to fighting off infections like Clostridioides difficile, and we’d love for you to join us by sharing some samples and information to help us learn more!

More Dysbiosis research and trials

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionUniversity of Pennsylvania
NIH-funded
Lab location1 site (Philadelphia, United States)
Project startMarch 9, 2022
Project endFebruary 28, 2027
Funding year2025
Award (this year)$179,426
NIH project number5K23AI163351-04
Project IDNIH-11044056 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are individuals who have experienced Clostridioides difficile infections, particularly those who own pets.

Less likely to help

Patients who do not have a history of Clostridioides difficile infections or do not own pets may not benefit from this research.

What this research studies

This research investigates the relationship between pet ownership and the gut microbiome's ability to resist Clostridioides difficile infections (CDI). It aims to understand how contact with pets may help restore gut health after antibiotic treatment, which often disrupts the natural microbiome. By analyzing the shared microbiota between pets and their owners, the study seeks to identify protective factors that could enhance recovery from CDI. Patients may be involved in providing samples and data to help uncover these connections.

Why it matters

Potential benefit: If successful, this research could lead to new strategies for preventing and treating Clostridioides difficile infections by leveraging the benefits of pet ownership.

How similar studies have gone: Previous studies have suggested that pet ownership may provide protective effects against CDI, indicating that this research builds on promising findings.

Where this research is happening

  • University of Pennsylvania
    Philadelphia, United States
    Active

Researchers

  • Principal investigator: Redding, Laurel Elizabeth — University of Pennsylvania
  • Study coordinator: Redding, Laurel Elizabeth

Related research

Other NIH-funded projects on the same topics.

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    This study is looking at how eating more fiber and less fat might help people, especially those with cancer, avoid infections from C. diff by changing the bacteria in their gut and how their bodies respond to antibiotics.

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  • Microbial Dysbiosis and Its Role in Pancreatic Cancer

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    NIH research Northwestern University · Chicago, United States · NIH-11624054

  • From Symbiosis to Dysbiosis: How Resolving Inflammation Could Restore Your Mouth’s Balance

    This grant explores how turning off the harmful inflammation in periodontitis and promoting natural healing could help restore the mouth’s healthy balance.

    NIH research Ada Forsyth Institute, INC. · Somerville, UNITED STATES · NIH-11621747

  • Antibiotics, gut health, and skin reactions in kids

    A small study in children will look at whether antibiotic use and gut bacteria play a role in hives and related symptoms that children sometimes get after antibiotics.

    NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11603169

  • Novel therapeutic to protect the gut after radiation

    A new GI-directed treatment given after radiation exposure may reduce gut damage and improve survival in people exposed to high-dose radiation.

    NIH research Columbia University Health Sciences · New York, United States · NIH-11572662

  • A new GI-focused treatment to reduce radiation damage after exposure

    A potential GI-targeted therapy given after radiation exposure may help protect the gut and improve survival in people affected by radiation injuries.

    NIH research Columbia University Health Sciences · New York, United States · NIH-11572658

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.